Results 231 to 240 of about 470,131 (305)

From residual risk to precision intervention: the evolving role of minimal residual disease in breast cancer management. [PDF]

Cancer Biol Med
Xu J, Fang K, Li X, Han L, Sun S, Sun T.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Distinct Clinical Significance of Minimal Residual Disease Detected by 7NB-mRNAs Expression in Bone Marrow at Different Time Points of High-Risk Neuroblastoma Patients. [PDF]

Biology (Basel)
Mon CY, Nay Win KH, Nishimura A, Nakatani N, Tamura A, Yamamoto N, Nino N, Uemura S, Saito A, Ishida T, Mori T, Hasegawa D, Okuno K, Kosaka Y, Ishizawa K, Umemoto M, Matsui T, Nagatani A, Nishimura N.   +18 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models. [PDF]

Nat Commun
Ott CA, Purwin TJ, Chen PY, Chowdhury S, Mellor GL, Luo K, Mersky GL, Tiago M, Madden WD, Varney SD, Erkes DA, Lamar J, Capparelli C, Bollag G, Aplin AE.   +14 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Multimodal tumor-agnostic ctDNA analysis for minimal residual disease detection and risk stratification in ovarian cancer: results from the MITO16a/MaNGO-OV2 trial. [PDF]

ESMO Open
Paracchini L, Velle A, Di Gennaro P, Mannarino L, Ancona L, Lorusso D, Cecere SC, Colombo N, Beltrame L, Fagotti A, Tasca G, Piemontese M, Arenare L, Califano D, Galdiero F, Zadro R, Chiodini P, Perrone F, Biagioli E, D'Incalci M, Romualdi C, Pignata S, Marchini S.   +22 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Global Hypomethylation as Minimal Residual Disease (MRD) Biomarker in Esophageal and Esophagogastric Junction Adenocarcinoma. [PDF]

Cancers (Basel)
Boldrin E, Piano MA, Volpato A, Alfieri R, Franco M, Morbin T, Masier A, Realdon S, Mattara G, Magni G, Rosato A, Pilati P, Fantin A, Curtarello M.   +13 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source