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Minimal residual disease in melanoma
Seminars in Surgical Oncology, 2001AbstractA number of specific genes encoding for melanosomal proteins are selectively expressed in melanocytes and melanomas. For detection of circulating melanoma cells, the expression of the tyrosinase gene is most widely used. Several cohorts of melanoma patients from single institutions have been analyzed by various research groups for the presence ...
N, Max, U, Keilholz
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Current Opinion in Hematology, 1995
The study of minimal residual disease has been fueled by the technologic advent of the polymerase chain reaction and basic developments identifying the genetic lesions involved in human malignancies. Thus far advances in identifying, cloning, and the subsequent polymerase chain reaction amplification of relevant genes have outpaced clinical studies ...
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The study of minimal residual disease has been fueled by the technologic advent of the polymerase chain reaction and basic developments identifying the genetic lesions involved in human malignancies. Thus far advances in identifying, cloning, and the subsequent polymerase chain reaction amplification of relevant genes have outpaced clinical studies ...
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Current Opinion in Hematology, 1998
A major limitation in the treatment of malignant disorders is the accurate and sensitive detection of minimal residual disease. It is clear that routine radiographic and pathologic studies are extremely important, however, lacking in sensitivity. Clearly, the goal of minimal residual disease detection is to make individual treatment decisions such that
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A major limitation in the treatment of malignant disorders is the accurate and sensitive detection of minimal residual disease. It is clear that routine radiographic and pathologic studies are extremely important, however, lacking in sensitivity. Clearly, the goal of minimal residual disease detection is to make individual treatment decisions such that
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Detection of Minimal Residual Disease
1995The ability to detect neoplastic infiltration is important not only for the accurate staging of disease at diagnosis but also to monitor the response to therapy. Although adult patients with advanced malignancies often achieve clinical complete remission, the majority of these patients ultimately relapse.
J, Gribben, L, Nadler
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2012
Disease relapse remains a major problem in a significant proportion of patients treated for cancer. Molecular monitoring of minimal residual disease (MRD), usually using a real-time quantitative PCR-based approach, is an important tool for risk stratification and prognostication and can be used as a guide for optimizing clinical management in these ...
Wesley O. Greaves, Rajyalakshmi Luthra
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Disease relapse remains a major problem in a significant proportion of patients treated for cancer. Molecular monitoring of minimal residual disease (MRD), usually using a real-time quantitative PCR-based approach, is an important tool for risk stratification and prognostication and can be used as a guide for optimizing clinical management in these ...
Wesley O. Greaves, Rajyalakshmi Luthra
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Markers of Minimal Residual Disease
1982Current methods employing tumour markers to detect small amounts of residual disease are reviewed with respect to human germ cell, colorectal and breast neoplasms. It is concluded that the assay of tumour markers in body fluids has only limited clinical value. Alternative approaches, such as are afforded by radioimmunodetection and immunocytochemistry,
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Techniques for Detection of Minimal Residual Disease
Leukemia & Lymphoma, 1995Analysis of leukemia-specific and leukemia-associated markers following standard or high-dose treatments is crucial in order to evaluate the efficacy of therapeutic strategies. During the last decade, several techniques have been proposed and used for detecting minimal residual disease (MRD). Each approach is characterized by advantages and limitations,
C, Carlo-Stella +3 more
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Managing Minimal Residual Malignant Disease
Oncology, 1986So-called complete remission of acute leukemia and other tumors frequently leaves minimal residual disease cells, sometimes causing an inflammatory response and often relapse. Although the remaining cells often have long generation times or may even be in G0 condition, they may form a new tumor mass.
G, Mathé, P, Reizenstein
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Kinetics of Minimal Residual Disease
1979The development of a rational approach to adjuvant chemotherapy of cancer depends upon at least four factors: 1. Recognition that micrometastases are frequently disseminated and established prior to the time of surgery for a primary cancer; 2.
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Minimal residual disease in acute leukaemia
European Journal of Cancer and Clinical Oncology, 1991THE PERSISTENCE of leukaemic cells throughout remission of the disease is increasingly recognised by modern methods. In particular polymerase’ chain reaction methodology allows to demonstrate the persistence of a few leukaemic cells (0.004-2.6%) in bone marrow of some patients with complete remission (CR) of acute lymphoblastic leukaemia (ALL) [l]. The
H H, Gerhartz, H, Schmetzer
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