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Current Opinion in Hematology, 1998
A major limitation in the treatment of malignant disorders is the accurate and sensitive detection of minimal residual disease. It is clear that routine radiographic and pathologic studies are extremely important, however, lacking in sensitivity. Clearly, the goal of minimal residual disease detection is to make individual treatment decisions such that
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A major limitation in the treatment of malignant disorders is the accurate and sensitive detection of minimal residual disease. It is clear that routine radiographic and pathologic studies are extremely important, however, lacking in sensitivity. Clearly, the goal of minimal residual disease detection is to make individual treatment decisions such that
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Minimal Residual Disease in Multiple Myeloma.
Presse medicaleMinimal Residual Disease (MRD) in multiple myeloma has emerged as a significant prognostic factor, guiding treatment strategies and enhancing patient outcomes.
N. Moukalled +3 more
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Managing Minimal Residual Malignant Disease
Oncology, 1986So-called complete remission of acute leukemia and other tumors frequently leaves minimal residual disease cells, sometimes causing an inflammatory response and often relapse. Although the remaining cells often have long generation times or may even be in G0 condition, they may form a new tumor mass.
G, Mathé, P, Reizenstein
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Minimal residual disease in melanoma
Seminars in Surgical Oncology, 2001AbstractA number of specific genes encoding for melanosomal proteins are selectively expressed in melanocytes and melanomas. For detection of circulating melanoma cells, the expression of the tyrosinase gene is most widely used. Several cohorts of melanoma patients from single institutions have been analyzed by various research groups for the presence ...
N, Max, U, Keilholz
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Detection of minimal residual disease
2001Publisher Summary Minimal residual disease (MRD) is defined as the presence of a small number of cancer cells in hematological malignancies usually below 1010 cells (that amount approximately corresponds to 1g of the total cancer cell burden in a human body).
A, Deptala, S P, Mayer
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2009
During the past 30 years, survival rates after allogeneic stem cell transplantation (SCT) have been improved substantially. These improvements have mostly been due to better graft matching using genomic HLA typing, GVHD prophylaxis, infection management, and supportive care [1-3]. The incidence of leukemia relapse and death rates after relapse, however,
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During the past 30 years, survival rates after allogeneic stem cell transplantation (SCT) have been improved substantially. These improvements have mostly been due to better graft matching using genomic HLA typing, GVHD prophylaxis, infection management, and supportive care [1-3]. The incidence of leukemia relapse and death rates after relapse, however,
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Multiple Myeloma Minimal Residual Disease
2016Assessment of minimal residual disease (MRD) is becoming standard diagnostic care for potentially curable neoplasms such as some acute leukemias as well as chronic myeloid and lymphocytic leukemia. Although multiple myeloma (MM) remains as an incurable disease, around half of the patients achieve complete remission (CR), and recent data suggests ...
Bruno, Paiva +2 more
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Detection of Minimal Residual Disease
1995The ability to detect neoplastic infiltration is important not only for the accurate staging of disease at diagnosis but also to monitor the response to therapy. Although adult patients with advanced malignancies often achieve clinical complete remission, the majority of these patients ultimately relapse.
J, Gribben, L, Nadler
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Minimal residual disease in gastrointestinal cancer
Seminars in Surgical Oncology, 2001AbstractTumor progression after curative resection of gastrointestinal carcinomas is probably caused by pre‐ or intraoperative tumor cell dissemination. Disseminated tumor cells are generally detected by immunohistochemistry‐ or PCR‐based molecular‐biology methods. A consensus on which is the most adequate detection method has not yet been found, which
P, Kienle, M, Koch
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Markers of Minimal Residual Disease
1982Current methods employing tumour markers to detect small amounts of residual disease are reviewed with respect to human germ cell, colorectal and breast neoplasms. It is concluded that the assay of tumour markers in body fluids has only limited clinical value. Alternative approaches, such as are afforded by radioimmunodetection and immunocytochemistry,
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