Results 61 to 70 of about 271 (212)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Dual-bionic titanium scaffolds based on a gyroid-sheet structure and BaTiO3 piezoelectric coating: a synergistic approach for bone defect repair

Materials Futures
Three-dimensional-printed porous titanium alloy implants have shown significant potential for addressing large segmental bone defects in weight-bearing applications.
Qi Wu, Zhen Tang, Changcheng Chen, Hai Huang, Dongmei Yu, Lei Shi, Shichao Yan, Shusen Bao, Xiaokang Li, Hao Wu, Zheng Guo   +10 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Nano-second pulsed laser ablation of inconel 718 and MMPCD for simultaneous optimal ablation rate and surface quality

Scientific Reports
This study investigates the ablation performance of Inconel 718, a nickel-based superalloy, and metal matrix polycrystalline diamond (MMPCD), a super composite, using a nano-second (ns) pulsed laser across a range of ablation conditions.
Ahmed Elkaseer, Islam H. Abdelgaliel, Jon Lambarri, Iban Quintana, Steffen Scholz, Mohamed F. Aly   +5 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Adaptive Trajectory Optimization for UAV-IRS Systems in 6G Thz Networks Using Multi Agent-DRL

Transport and Telecommunication
Future 6th Generation (6G) networks will rely on Terahertz (THz) wireless communication as their main enabler for delivering both ultra-high data speed and minimal delay.
Elmadina Nahla Nur, Saeed Rashid A., Saeid Elsadig, Awouda Ala Eldin, Mujlid Hana M., Elshafie Hashim   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Aerodynamic Optimization Design of a Supergravity Centrifuge: A Low-Resistance Strategy

Applied Sciences
Wind resistance optimization is crucial for enhancing the rotational speed of supergravity centrifuges. We conducted a study using computational fluid dynamics on the Centrifugal Hypergravity and Interdisciplinary Experiment Facility (CHIEF) under ...
Yi-Nan Guo, Yi Yang, Wei-An Lin, Jian-Qun Jiang, De Ding   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source