Results 51 to 60 of about 13,046,168 (188)

Platform study of genotyping-guided precision medicine for rare solid tumours: a study protocol for a phase II, non-randomised, 18-month, open-label, multiarm, single-centre clinical trial testing the safety and efficacy of multiple Chinese-approved targeted drugs and PD-1 inhibitors in the treatment of metastatic rare tumours

open access: yesBMJ Open, 2021
Introduction Limited clinical studies have been conducted on rare solid tumours, and there are few guidelines on the diagnosis and treatment, including experiences with targeted therapy and immunotherapy, of rare solid tumours in China, resulting in ...
Hui Wang   +22 more
doaj   +1 more source

Efficacy, safety and dose selection of AZD3759 in patients with untreated EGFR-mutated non-small-cell lung cancer and central nervous system metastases in China (CTONG1702-Arm 8): a multi-center, single-arm, phase 2 trialResearch in context

open access: yesEClinicalMedicine, 2023
Summary: Background: Central nervous system (CNS) metastases is inevitable for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). AZD3759 is a novel EGFR-TKI with impressive CNS penetration.
Si-Yang Maggie Liu   +25 more
doaj   +1 more source

Sion's mini-max theorem and Nash equilibrium in a multi-players game with two groups which is zero-sum and symmetric in each group [PDF]

open access: yes, 2018
We consider the relation between Sion's minimax theorem for a continuous function and a Nash equilibrium in a multi-players game with two groups which is zero-sum and symmetric in each group. We will show the following results. 1. The existence of Nash
Satoh, Atsuhiro, Tanaka, Yasuhito
core   +2 more sources

A unified minimax result for restricted parameter spaces

open access: yes, 2012
We provide a development that unifies, simplifies and extends considerably a number of minimax results in the restricted parameter space literature. Various applications follow, such as that of estimating location or scale parameters under a lower (or ...
Marchand, Éric, Strawderman, William E.
core   +1 more source

DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long‐Term Survival in Ischemic Stroke: A Prospective Cohort Study

open access: yesAnnals of Neurology, EarlyView.
Objective Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation.
B. Díaz‐Benito   +10 more
wiley   +1 more source

Sequential Minimax Search for Multi-Layer Gene Grouping

open access: yesIEEE Access, 2019
Many areas of exploratory data analysis need to deal with high-dimensional data sets. Some real life data like human gene have an inherent structure of hierarchy, which embeds multi-layer feature groups.
Wenting Wang   +3 more
doaj   +1 more source

Accounting for grouped predictor variables or pathways in high-dimensional penalized Cox regression models

open access: yesBMC Bioinformatics, 2020
Background The standard lasso penalty and its extensions are commonly used to develop a regularized regression model while selecting candidate predictor variables on a time-to-event outcome in high-dimensional data. However, these selection methods focus
Shaima Belhechmi   +3 more
doaj   +1 more source

Favoring the hierarchical constraint in penalized survival models for randomized trials in precision medicine

open access: yesBMC Bioinformatics, 2023
Background The research of biomarker-treatment interactions is commonly investigated in randomized clinical trials (RCT) for improving medicine precision. The hierarchical interaction constraint states that an interaction should only be in a model if its
Shaima Belhechmi   +4 more
doaj   +1 more source

Mellin Representation for the Heavy Flavor Contributions to Deep Inelastic Structure Functions [PDF]

open access: yes, 2004
We derive semi--analytic expressions for the analytic continuation of the Mellin transforms of the heavy flavor QCD coefficient functions for neutral current deep inelastic scattering in leading and next-to-leading order to complex values of the Mellin ...
Abbott   +69 more
core   +2 more sources

Search versus Knowledge: An Empirical Study of Minimax on KRK [PDF]

open access: yes, 2003
This article presents the results of an empirical experiment designed to gain insight into what is the effect of the minimax algorithm on the evaluation function. The experiment’s simulations were performed upon the KRK chess endgame.
Bratko, Ivan   +2 more
core  

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