Results 121 to 130 of about 99,604 (299)
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Preliminary analysing of experimental data for the development of high Cr Alloy Creep damage Constitutive Equations [PDF]
, 2012 This conference paper presents the current research of preliminary analysing of experimental data for the development of high Cr Alloy Creep damage Constitutive Equations (such as P91 alloy). Firstly, it briefly introduces the background of general creep
An, Lili +3 more
core
Is minimum creep rate a fundamental material property?
, 1990 Ice engineering problems require solutions in terms of specific design stress, strain or damage limits. Engineers must know the interdependence between stress, strain, damage state and time for a given ice body at a given temperature distribution and loading history.
openaire +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Experimental study and model for healthy and pathological synovial fluid [PDF]
, 2011 This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011) +2 more
core
Irreversible thermodynamics of creep in crystalline solids
, 2013 We develop an irreversible thermodynamics framework for the description of creep deformation in crystalline solids by mechanisms that involve vacancy diffusion and lattice site generation and annihilation. The material undergoing the creep deformation is
Boettinger, W. J. +3 more
core +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Evaluation of a high performance, fixed-ratio, traction drive [PDF]
, 1983 A test program was initiated to evaluate the key operational and performance factors associated with the Nasvytis multiroller concept. Two sets of Nasvytis drives, each of slightly geometry, were parametrically tested on a back to back test stand ...
Anderson, N. E. +2 more
core +1 more source