Results 101 to 110 of about 7,958 (294)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Creep Properties of Grade 91 Steel Steam Generator Tube at 923K

open access: yes, 2013
Creep-rupture properties of T91 steam generator (SG) tube steel have been examined at 923K in normalised and tempered condition in the stress range 55-150MPa.
Samuel, E. Isaac   +3 more
core   +1 more source

Observations of creep of polar firn at different temperatures [PDF]

open access: yesThe Cryosphere
To improve our understanding of firn compaction and deformation processes, constant-load compressive creep tests were performed on specimens from a Summit, Greenland (72°35′ N, 38°25′ W) firn core that was extracted in June 2017.
Y. Li, Y. Li, K. Keegan, I. Baker
doaj   +1 more source

The importance of creep strain in linking together the Wilshire equations for minimum creep rates and times to various strains (including the rupture strain): an illustration using 1CrMoV rotor steel [PDF]

open access: yesJournal of Materials Science, 2013
This paper highlights the observation that the Wilshire equations for failure times and times to various strains, as reported in the original literature, may not be the most appropriate ones for all materials—including the one selected in this study. Further, such appropriateness can be determined by looking at the consistencies between the parameter ...
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Creep-seepage evolution of coal under different temperatures, confining pressures, and gas pressures

open access: yesMeikuang Anquan
In order to realize the efficient mining of deep coalbed methane, through studying the creep deformation and permeability evolution laws of coal mass under different temperatures, confining pressures and gas pressures, we obtain the coupling relationship
Leili ZHANG   +4 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Development of Advanced Creep Damage Constitutive Equations for Low CR Alloy Under Long-Term Service

open access: yes
Low Cr alloys are mostly utilized in structural components such as steam pipes, turbine generators and reactor pumps operating at high temperatures from 400℃ to 700℃ in nuclear power plants.
Xu, Qihua
core  

Application of the Modified Hyperbolic Sine Law for Creep Rate and Creep Lifetime Equation to Grade 91 Steel

open access: yes
The minimum creep rate and the Monkman-Grant relationship are currently essential methods for predicting creep life. The accuracy of traditional power law minimum creep rate equation is unsatisfactory when applied to a wide range of stresses and ...
Lu, Joan, Xu, Qiang, Wu, Yuandi
core   +1 more source

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