Results 91 to 100 of about 99,604 (299)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Study on creep behavior and microstructure of a Fe–Cr–Al–Nb–W ferrtic heat-resistant steel based on C, N and Al element control

Materials Research Express, 2020
In this work, the effects of C, N, and Al on the microstructures and creep properties of Fe–Cr–Al–Nb–W ferritic alloys were investigated through scanning electron microscopy, x-ray diffractometry, as well as uniaxial creep testing and hardness testing ...
Shanjun Zhang, Junjie Shen, Hui Kang, Fuyong Hu   +3 more
doaj   +1 more source

Creep behavior of tungsten fiber reinforced niobium metal matrix composites [PDF]

Tungsten fiber reinforced niobium metal matrix composites were evaluated for use in space nuclear power conversion systems. The composite panels were fabricated using the arc-spray monotape technique at the NASA Lewis Research Center.
Grobstein, T. L.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Understanding creep behavior of polycrystalline TiAl alloys by molecular dynamics simulations

Journal of Materials Research and Technology
The effect of temperature and stress on the creep behavior of polycrystalline γ-TiAl alloys was investigated by molecular dynamics simulations to gain a detailed understanding of the deformation mechanism at the atomic level.
Yunlou Wang, Hangyu Yue, Xinying Xu, Zhenquan Liang, Hongwu Gao, Rengeng Li   +5 more
doaj   +1 more source

Creep-fatigue life assessment of high-temperature weldments using the linear matching method [PDF]

, 2012
This poster discusses Creep-fatigue life assessment of high-temperature weldments using the linear matching ...
Chen, Haofeng, Gorash, Yevgen
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Study on the creep behavior of forged Inconel 718 alloy tailored by grain configuration and δ phase

Journal of Materials Research and Technology
Nickel-based superalloys have been widely applied in the manufacturing of aero-engine hot-end components serving under extreme conditions. The development of advanced aero-engine technology puts forward demands for deeper understanding the underlying ...
Xiangyu Huang, Hongjun Zhang, Jiawang Liu, Qiulin Kuang, Yaqiang Tian, Xiaoping Zheng, Liansheng Chen, Jingqi Chen, Xuetong Li, Zhenhua Bai   +9 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Study on creep rate prediction model of compacted graphite cast iron under wide range of temperature and stress based on PHNN

Jixie qiangdu
ObjectiveAiming at the problem that existing models for predicting the minimum creep rate of compacted graphite cast iron under wide temperature and stress ranges still have large errors, optimization research on the prediction method was carried out to ...
MA Tian, JING Guoxi, XU Hongjing, TAO Shuai, DONG Changlong, HUANG Lirong, MA Teng   +6 more
doaj