Results 81 to 90 of about 99,604 (299)

Spatial fluctuations in transient creep deformation

, 2011
We study the spatial fluctuations of transient creep deformation of materials as a function of time, both by Digital Image Correlation (DIC) measurements of paper samples and by numerical simulations of a crystal plasticity or discrete dislocation ...
Alava M J, Amandine Miksic, Barrat J L, Berthier L, Coffin D W, Csikor F F, Dauchot O, Jari Rosti, Juha Koivisto, Lasse Laurson, Louchet F, Mikko J Alava, Monkman F C, Mustalahti M, Nabarro F R N, Pertsinidis A, Salminen L I, Van der Giessen E, Zaiser M   +18 more
core   +1 more source

A laboratory study on cold-mix, cold-lay emulsion mixtures [PDF]

, 2009
This paper describes laboratory experiments and presents results for the performances of cold-mix, cold-lay emulsion mixtures. The main objective of the experiments was to evaluate and improve the properties of the cold mixtures.
Aderson A., Asphalt Institute, British Standards Institution, British Standards Institution, British Standards Institution, British Standards Institution, British Standards Institution, Cooper K. E., Energy Efficiency Office of the Department of the Environment, Highway Authorities and Utilities Committee (HAUC), I. N. A. Thanaya, J. P. Forth, Leech D., Milton L. J., Ministry of Public Works Republic of Indonesia (MPW-RI), Nichols J. C., Nikolaides A. F., Nikolaides A. F., Pascoe R. D., S. E. Zoorob, Suparma L. B., Thanaya I. N. A., Whitoeak D., Zoorob S. E.   +23 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Relationship between Minimum Creep Rate and Rupture Life for a Die-Cast Mg-Al-Mn Alloy

MATERIALS TRANSACTIONS, 2008
Creep rupture tests were performed for a die-cast Mg-Al-Mn alloy, AM50, at 34 kinds of creep conditions in the temperature range between 423 and 498K. The creep curve is characterized by a minimum in the creep rate followed by an extended accelerating stage.
Yoshihiro Terada, Tatsuo Sato
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Role of dynamically precipitated long-period stacking ordered (LPSO) plates on the creep behavior of hot-extruded Mg–Zn–Y alloys with multimodal microstructure

Journal of Materials Research and Technology
α-Mg/long-period stacking ordered (LPSO) duplex alloys with multimodal microstructures exhibit exceptional mechanical properties. In this study, the influence of dynamically precipitated LPSO plate on the creep behavior of hot-extruded Mg–1Zn–2Y and Mg-0.
Takahiro Mineta, Wataru Bando, Soya Nishimoto, Naoaki Tsunekawa, Daisuke Takahashi, Hiroyuki Sato, Koji Hagihara, Michiaki Yamasaki   +7 more
doaj   +1 more source

Microscopic dynamics and failure precursors of a gel under mechanical load

, 2018
Material failure is ubiquitous, with implications from geology to everyday life and material science. It often involves sudden, unpredictable events, with little or no macroscopically detectable precursors.
Aime, Stefano, Cipelletti, Luca, Ramos, Laurence   +2 more
core   +3 more sources