Results 81 to 90 of about 7,958 (294)

Study on creep behavior and microstructure of a Fe–Cr–Al–Nb–W ferrtic heat-resistant steel based on C, N and Al element control

Materials Research Express, 2020
In this work, the effects of C, N, and Al on the microstructures and creep properties of Fe–Cr–Al–Nb–W ferritic alloys were investigated through scanning electron microscopy, x-ray diffractometry, as well as uniaxial creep testing and hardness testing ...
Shanjun Zhang, Junjie Shen, Hui Kang, Fuyong Hu   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Creep behaviour of the creep resistant MgY3Nd2Zn1Mn1 alloy

, 2008
Creep, microstructure and failure of the squeeze cast MgY3Nd2Zn1Mn1 alloy were investigated. The tensile creep tests were performed at 300 °C and constant load in the stress range 30-80 MPa.
Hnilica, F., Smola, B., Stulíková, I., Očenášek, V., Janik, Vit   +4 more
core   +1 more source

Study on creep rate prediction model of compacted graphite cast iron under wide range of temperature and stress based on PHNN

Jixie qiangdu
ObjectiveAiming at the problem that existing models for predicting the minimum creep rate of compacted graphite cast iron under wide temperature and stress ranges still have large errors, optimization research on the prediction method was carried out to ...
MA Tian, JING Guoxi, XU Hongjing, TAO Shuai, DONG Changlong, HUANG Lirong, MA Teng   +6 more
doaj  

Study on the creep behavior of forged Inconel 718 alloy tailored by grain configuration and δ phase

Journal of Materials Research and Technology
Nickel-based superalloys have been widely applied in the manufacturing of aero-engine hot-end components serving under extreme conditions. The development of advanced aero-engine technology puts forward demands for deeper understanding the underlying ...
Xiangyu Huang, Hongjun Zhang, Jiawang Liu, Qiulin Kuang, Yaqiang Tian, Xiaoping Zheng, Liansheng Chen, Jingqi Chen, Xuetong Li, Zhenhua Bai   +9 more
doaj   +1 more source

Relationship between Minimum Creep Rate and Rupture Life for a Die-Cast Mg-Al-Mn Alloy

MATERIALS TRANSACTIONS, 2008
Creep rupture tests were performed for a die-cast Mg-Al-Mn alloy, AM50, at 34 kinds of creep conditions in the temperature range between 423 and 498K. The creep curve is characterized by a minimum in the creep rate followed by an extended accelerating stage.
Yoshihiro Terada, Tatsuo Sato
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Commercialisation of impression creep testing

Ubiquity Proceedings, 2018
Impression creep testing is a technique in which the deformation resulting from load applied via a rectangular indenter can be converted relatively straightforwardly into a proxy for creep minimum strain rate.
T. Gallacher, J. Eaton-McKay, S. Brett, S. Jacques, C. Austin, A. Wisbey   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source