Results 71 to 80 of about 16,947,670 (194)

Maximum Cumulative Ratio (MCR) as a Tool for Assessing the Value of Performing a Cumulative Risk Assessment

, 2011
Due to the vast number of possible combinations of chemicals to which individuals are exposed and the resource-intensive nature of cumulative risk assessments, there is a need to determine when cumulative assessments are most required.
Paul S. Price, Xianglu Han
core   +1 more source

Molecular insights into functional differences between mcr-3- and mcr-1-mediated colistin resistance [PDF]

, 2018
The global emergence of plasmid-mediated colistin resistance genes mcr-1 and mcr-3 has threatened the role of the “last resort” drug colistin in the defense against infections caused by multidrug-resistant Gram-negative bacteria.
Shen, Yingbo, Wang, Yang, Yang, Lu, Liu, Zhihai, Liu, Dejun, Yin, Wenjuan, Li, Hui, Walsh, Timothy, Shao, Bing   +8 more
core   +1 more source

Controlling Self‐Doping in Conjugated Polyelectrolyte Copolymers to Vary the Threshold Voltage in OECTs

Advanced Electronic Materials, EarlyView.
Two series of self‐doped conjugated polyelectrolytes are synthesized from a non‐self‐dopable building block 3MEEET and a self‐dopable building‐block 3HOT−[TMA+] or 3HOT−[SO3H] enabling precise control over the degree of self‐doping, which in turn directly governs the threshold voltage (VT) in OECTs over a wide range of 700 mV.
Julian Hungenberg, Andreas W. Erhardt, Adrian Hochgesang, John Mohanraj, Lys Sprenger, Sahar Salehi, Christopher R. McNeill, Mukundan Thelakkat   +7 more
wiley   +1 more source

Construction and optimization of ecological security patterns in ecologically fragile areas: a case study of Lanzhou City, China

Frontiers in Environmental Science
IntroductionUnder China’s strategic initiative for ecological conservation and high-quality development in the Yellow River Basin, establishing Ecological Security Patterns (ESPs) has emerged as a crucial approach to reconcile ecological preservation ...
Jianhong Dong, Lina Li, Wenjin Yang, Benteng Liu, Xinhong Zhang   +4 more
doaj   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Colistin Resistance Mediated by Mcr-3-Related Phosphoethanolamine Transferase Genes in Aeromonas Species Isolated from Aquatic Environments in Avaga and Pakro Communities in the Eastern Region of Ghana [PDF]

Samiratu Mahazu,1,2 Isaac Prah,1,3 Yusuke Ota,1 Takaya Hayashi,3 Masato Suzuki,4 Mitsunori Yoshida,5 Yoshihiko Hoshino,5 Yukihiro Akeda,6 Toshihiko Suzuki,7 Tomoko Ishino,2 Anthony Samuel Ablordey,8 Ryoichi Saito1 1Department of Molecular Microbiology ...
Yoshida M, Saito R, Suzuki T, Mahazu S, Suzuki M, Prah I, Ishino T, Hoshino Y, Akeda Y, Hayashi T, Ablordey AS, Ota Y   +11 more
core  

Triazole Derivatives as Potential MCR-1 Inhibitors: A Promising Approach to Overcome Colistin Resistance [PDF]

BACKGROUND/AIMS: Colistin, a last-resort antibiotic, is crucial in treating multidrug-resistant Gram-negative infections. However, the rise of colistin resistance, particularly due to plasmid-mediated MCR-1 genes, poses a significant challenge.
Emine Erdağ, Cenk Serhan Özverel, Cemile Bağkur   +2 more
core   +1 more source

Resistance to the “Last Resort” Antibiotic Colistin:A Single-Zinc Mechanism for Phosphointermediate Formation in MCR Enzymes [PDF]

, 2020
MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the “last-resort” antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports
Visitsatthawong, Surawit, Mulholland, Adrian J, Oliveira, A Sofia F, Mulholland, Adrian, Lythell, Emily, Hinchliffe, Philip, Lee, Vannajan Sanghiran, Lang, Eric J M, Suardíaz, Reynier, Oliveira, Sofia, Lang, Eric, Fey, Natalie, Surawatanawong, Panida, Rungrotmongkol, Thanyada, Spencer, James, Hanpaibool, Chonnikan, Suardíaz Delrío, Reynier   +16 more
core   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Influence of large open-pit mines on the construction and optimization of urban ecological networks: A case study of Fushun City, China.

PLoS ONE
Under the long-term effect of mineral resource exploitation, especially open-pit mining, ecosystems are severely disturbed. Constructing and optimizing urban ecological networks influenced by open-pit mines based on mine-city coordination helps integrate
Dongmei Feng, Ge Bai, Liang Wang
doaj   +1 more source