Results 71 to 80 of about 16,992,457 (248)

Cumulative Causation and Evolutionary Micro-Founded Technical Change : A Growth Model with Integrated Economies [PDF]

We propose to develop in this paper an alternative approach to the New Growth Theory to analyse growth rate divergence among integrated economies. The model presented here considers economic growth as a disequilibrium process.
André Lorentz, Patrick Llerena
core   +2 more sources

Supranational surveillance of antimicrobial resistance: The legacy of the last decade and proposals for the future

, 2010
Antimicrobial resistance among clinically important bacteria is widely acknowledged as a major global public health threat. A decade ago, several supranational surveillance initiatives were introduced. Few of them are still ongoing, and only one features
CORNAGLIA, Giuseppe, Giske CG, European Study Group on Antimicrobial Resistance Surveillance   +2 more
core   +1 more source

Cumulative distribution of the minimum reserve ratio.

, 2023
Cumulative distribution of the minimum reserve ratio.
Daisuke Takabatake (14846084), Ayumi Yuyama (14846087), Yoshio Kajitani (10325731), Tomomi Ishikawa (107125), Wolfgang Kröger (14846090)   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Optimization of Tourism Destination Road Network Layout Based on MCR and Circuit Theory Model

Journal of Engineering, Project, and Production Management
The development of the tourism industry drives the growth of transportation demand in tourist destinations. The road network layout directly affects the tourist experience and local development.
Yefan Zou, Ninger Ma
doaj   +1 more source

Ecological Network Construction of Sea-Island City Based on MSPA and MCR Model

Shuitu baochi yanjiu, 2023
In order to solve the ecological environment problems caused by the rapid development, an effective way to balance the development of sea-island city and ecological protection was explored.
QIN Zibo, XUAN Jin, HUANG Liujing, LIU Xingzhao   +3 more
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A spatiotemporal analysis framework of the ecological security pattern based on the ecological “source–surface–corridor” and its implications

Frontiers in Ecology and Evolution
A reasonable ecological security pattern can improve landscape connectivity, promote biological circulation, maintain ecological processes, and improve regional ecosystem service functions and human well-being.
Shuai Zhang, Yihao Chen, Jiwei Li, Jiwei Li, Qingqing Ye, Weiqiang Chen, Weiqiang Chen, Xiuli Wang, Xiuli Wang, Hejie Wei, Hejie Wei, Qinghu Jiang, Long Guo   +12 more
doaj   +1 more source