Results 81 to 90 of about 16,992,457 (248)
Shuitu baochi yanjiu, 2023 [Objective] This study aims to accurately identify key nodes and regions of ecological protection, and to construct ecological corridors in a reasonable way for the sustainable development of the ecosystem.
ZHANG Wenjia, FU Yongyong, WANG Xiaojun
doaj
Risk Aversion in Cumulative Prospect Theory [PDF]
This paper characterizes the conditions for risk aversion in cumulative prospect theory where risk aversion is defined in the strong sense (Rothshild Stiglitz 1970).
Horst Zank, Schmidt, Ulrich
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050 [PDF]
Background: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed ...
GBD, 2021 Antimicrobial Resistance Collaborators +1 more
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
The reliability mathematical model of load-sharing parallel systems based on fatigue cumulative damage [PDF]
, 2012 Conventional reliability models for parallel systems are not applicable for the analysis of parallel systems with load transfer and sharing. In this short communication, firstly, the direct reliability model of load-sharing parallel systems is presented ...
He, Xiuyun, Hao, Guangbo, Xie, Liyang
core +1 more source
Ecological IndicatorsCultural heritage embodies the profound cultural connotations accumulated during the evolution of human civilization. Its protection and development are of great significance for cultural continuity, the preservation of national spirit, and sustainable ...
Yipeng Ge +6 more
doaj +1 more source
Predictive Leakage Estimation using the Cumulative Minimum Night Flow Approach
, 2017 Several methods have been used in estimating leakages. Although the minimum night flow analysis method has been widely used in leakage estimation, the cumulative minimum night flow method is one method that can yield comparatively good leakage estimates.
Makaya Eugine
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
LandRailway heritage corridors, which integrate cultural history and natural landscapes, face limitations within the conventional “axis extension” construction model, where protection zones are radiated from existing railway lines.
Xinyi Li, Haishan Xia
doaj +1 more source