Results 61 to 70 of about 16,992,457 (248)

Spatial Construction and Optimization of Urban–Rural Heritage Corridors from the Perspective of Online Public Attention: A Case Study of Nanchang

open access: yesLand
Urban–rural governance and planning systems, as viewed through the lens of online public attention, are reshaping approaches to achieving coordinated development of cultural heritage conservation and urban space.
Fen Xiao   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Portfolio Selection with minimum transaction lots: an approach with dual expected utility [PDF]

open access: yes
In this paper we analyse the portfolio selectionproblem with minimum transactionlots in the context of non-expected utility theory. We assume that the decisionmaker ranks the alternatives by using a specific DualExpectedUtility.
Floriana Filippini, Marisa Cenci
core  

Resource guide for student's cumulative folders [PDF]

open access: yes, 2001
Plan BThe purpose of this study was to develop a resource guide for teachers, counselors, parents, and administrators at North High School in Eau Claire, WI. Primary data was collected by randomly selecting cumulative folders from each grade level (9-12)
Braaten, Kathleen
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Identifying Cross-Regional Ecological Compensation Based on Ecosystem Service Supply, Demand, and Flow for Landscape Management

open access: yesDiversity
Clarifying the issues related to the supply, demand, and flow of ecosystem services is crucial for regional landscape management. This study employs the equivalence factor method and demand index quantification to analyze the supply and demand of ...
Hejie Wei   +5 more
doaj   +1 more source

Construction and Optimization of Ecological Network in the Main Urban Area of Qiqihar City

open access: yesShuitu baochi yanjiu, 2021
The main urban area of Qiqihar City is an important node of the Harbin-Daqing-Qiqihar Industrial Corridor. In recent years,industrialization has led to the fragmentation of ecological patches and the decline of ecological benefits. Building an ecological
XIE Jing, LI Wen, JIA Jia, ZHAO Hengsong
doaj  

Innovation, diffusion and cumulative causation: changes in the Spanish growth regime, 1960-2001 [PDF]

open access: yes
This article presents a model of macroeconomic growth that combines in a single formalization two complementary views on innovation and economic growth, the technology-gap approach and the Kaldorian theory of cumulative causation. The model suggests that
Castellacci, Fulvio
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

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