Results 91 to 100 of about 1,540,522 (297)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Prevalence of Antibiotic and Toothpaste Sensitivity Found in Oral Streptococcal Isolates in Healthy Individuals in the Okada Community of Nigeria [PDF]

, 2017
Background: This study aimed to determine the prevalence, antibiotic, and toothpaste sensitivity of oral streptococcal isolates in healthy individuals in the Okada community of Nigeria.
Mitsan, O. (Olley), Okwu, M. U. (Maureen)   +1 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

IN VITRO EFFICACY OF CICLOPIROX AGAINST CARBAPENEM RESISTANT ENTEROBACTERIACEAE

Pakistan Armed Forces Medical Journal, 2021
Objective: To determine the in vitro efficacy of Ciclopirox against Carbapenem Resistant Enterobacteriaceae by determining its minimum inhibitory concentration by micro agar dilution method. Study Design: Quasi experimental study.
Maliha Ansari, Hassan Ikram, Nadia Saad, Aaminah Hanif, Aiza Sadia, Qazi Ikram Ullah   +5 more
doaj  

Evaluation of anti-tuberculosis potentials of selected medicinal plants in Endau Rompin, Johor, Malaysia [PDF]

, 2018
Tuberculosis (TB) remains an escalating health crisis globally which prompts new approaches to find more effective therapeutic strategies. Medicinal plants of Malaysia have a significant role to play in being able to provide new therapeutic remedies. The
Sanusi, Shuaibu Babaji
core  

Radial Distribution of Near-UV Flux in Disc Galaxies in the range 0

, 2009
(Abridged) The goal of this paper is to quantify the changes on the SF distribution within the disc galaxies in the last ~8 Gyr. We use as a proxy for the SF radial profile the Near-UV surface brightness distributions, allowing suitably for extinction ...
Adelman-McCarthy, Azzollini, Azzollini, Bakos, Barden, Bell, Bell, Bell, Bertin, Bianchi, Boissier, Boissier, Bolzonella, Bournaud, Brinchmann, Bruzual, Calzetti, Cassata, Cepa, Coe, Conselice, Conselice, Conselice, Cowie, de Jong, Debattista, Elmegreen, Elmegreen, Erwin, Foyle, Freeman, Giavalisco, Gil de Paz, Gil de Paz, Gil de Paz, Ho, Ho, Hodge, Hodge, Hodge, Huchra, I. Trujillo, Ilbert, J. E. Beckman, James, Jansen, Kennicutt, Kennicutt, Kennicutt, Kent, Koopman, Kroupa, Lilly, Madau, Madau, McIntosh, Miller, Mo, Monet, Moore, Muñoz-Mateos, Möllenhoff, Petit, Phookun, Pohlen, Popescu, Pérez-González, R. Azzollini, Ravindranath, Rix, Roberts, Roskar, Roskar, Rudnick, Salpeter, Schaye, Schlegel, Seigar, Shen, Somerville, Somerville, Thilker, Trujillo, Trujillo, Trujillo, Tuffs, van den Bosch, van der Kruit, Wolf, Wolf, Wolf   +90 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Nisin Induced Morphological Changes and Disruption of Growth in Eschericia.Coli [PDF]

, 2015
Nisin is a 34 residue long cationic lanthionine antibiotic produced by Lactococcus lactis and antimicrobial activity against a broad spectrum of gram-positive bacteria.
Sweta, Chandra
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source