Results 121 to 130 of about 1,540,522 (297)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Efficacy of 2-Phenoxyethanol as an Anaesthetic for Adult Redline Torpedo Fish, Sahyadria denisonii (Day 1865)

International Journal of Zoology, 2014
Efficacy of 2-phenoxyethanol for redline torpedo fish exposed to five concentrations (200, 300, 400, 500, and 600 μlL−1) was evaluated. The time periods necessary for each characteristic stage of induction and recovery were recorded.
Anna Mercy Thoranam Varkey, Sajan Sajeevan   +1 more
doaj   +1 more source

Antifungal Profiles of Extracts of Vitellaria paradoxa (Shea-Butter) Bark [PDF]

, 2009
The antifungal profiles of the bark of Vitellaria paradoxa were examined against clinical isolates of Aspergillus niger, Aspergillus flavus, Epidermophyton floccosum, Microsporum audouinii and Trichophyton mentagrophytes.
Ahmed, R. N., Igunnugbemi, O. O., Sani, A.   +2 more
core   +1 more source

Investigation of conduction band structure, electron scattering mechanisms and phase transitions in indium selenide by means of transport measurements under pressure

, 1996
In this work we report on Hall effect, resistivity and thermopower measurements in n-type indium selenide at room temperature under either hydrostatic and quasi-hydrostatic pressure.
%A. Polian, A. Bourdon, A. Chevy, A. Chevy, A. Chevy, A. Polian, A. Segura, A. Segura, A. Segura, A.A. Ismailov, A.R. Gon-|Ati, B. Marí, B.R. Nag, C. Ulrich, C. Ulrich, C. Ulrich, D. Errandonea, D.F. Howell, E. Kress-Rogers, E. Kress-Rogers, E. Kress-Rogers, E.M. Conwell, F. Stern, H. Brooks, I.G. Lang, J. F. Sánchez-Royo, J. Martínez-Pastor, J. Riera, J.C. Portal, J.L. Van der Pauw, J.M. Besson, J.M. Besson, K.R. Allakhverdiev, M. Gauthier, M. Mejatty, M. Nishikawa, N. Gasanly, N. Kuroda, N. Kuroda, N. Kuroda, N. Kuroda, N. Piccioli, P. Grima, P. Kir`eev, R. Fivaz, R. Nicholas, R. Pareja, U. Schwarz, V. Mun-|Atoz   +48 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Numerical Analysis of the Reaction-diffusion Equation for Soluble Starch and Dextrin as Substrates of Immobilized Amyloglucosidase in a Porous Support by Using Least Square Method

Applied Food Biotechnology, 2015
In this study, substrates concentration profile has been studied in a porous matrix containing immobilized amyloglucosidase for glucose production. This analysis has been performed by using of an analytical method called Least Square Method and results ...
Ali Izadi, Sobhan Mosayebi dorcheh, Hamid Rashedi   +2 more
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. [PDF]

, 2018
BackgroundLyme disease accounts for >90% of all vector-borne disease cases in the United States and affect ~300,000 persons annually in North America.
Ambati, Aditya, Babar, Mustafeez Mujtaba, Inayathullah, Mohammed, Kim, Kwang-Min, Maguire, Peter, Parekh, Mansi B, Pothineni, Venkata Raveendra, Potula, Hari-Hara Sk, Rajadas, Jayakumar, Tayebi, Lobat   +9 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Three phase boost rectifier design [PDF]

, 2012
An electric power can be converted from one form to another form by using power electronics devices. The function of power electronics circuits by using semiconductor devices as switch is modifying or controlling a voltage.
Saher, Rohaizan
core