Results 111 to 120 of about 439,248 (349)

Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr) [PDF]

, 2013
The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to have essentially linear gold atom coordination geometries defined by phosphane-P and thiolate-S atoms, and exhibit minimum inhibitory ...
Abdul Halim, Siti Nadiah, Ang, Kok Pian, Cheah, Yoke Kqueen, Fairuz, Zainal Abidin, Goh, Zheng Jie, Khoo, Chai Hoon, Ng, Seik Weng, Seng, Hoi Ling, Sim, Jiun Horng, Tiekink, Edward R. T., Yeo, Chien Ing   +10 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

1266. Characterization of Shifts in Minimum Inhibitory Concentrations During Treatment with Cefiderocol or Comparators in the Phase 3 CREDIBLE-CR and APEKS-NP Studies [PDF]

, 2020
Miki Takemura, Yoshinori Yamano, Yuko Matsunaga, Mari Ariyasu, Roger Echols, Tsutae Den Nagata   +5 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The minimum inhibitory concentration of different candidal disinfecting agents

Saudi Journal of Medicine and Medical Sciences, 2015
Purpose: Despite the availability of a large number of commercial denture cleansing products, only a few are used by wearers of dentures. This may be due to negligence on the part of the wearers of dentures and or the high cost of the products.
Aiman A Ali, Fahad A Al Harbi
doaj   +1 more source

Deciphering Polymyxin B Minimum Inhibitory Concentration from Colistin Minimum Inhibitory Concentration and Vice Versa: An Analysis on 156 Carbapenem-Resistant Enterobacteriaceae Isolates

Indian Journal of Medical Microbiology, 2018
The susceptibility determination to polymyxins (colistin and polymyxin B) remains a challenge for clinical microbiology laboratories. We evaluated the minimum inhibitory concentration (MIC) of both antimicrobials by the broth microdilution method in a selected subset of 156 carbapenem-resistant Enterobacteriaceae (CRE) isolates.
Bijayini, Behera, Jayanti, Jena, Punyatoya, Kar, Srujana, Mohanty, Ashoka, Mahapatra   +4 more
openaire   +2 more sources

Minimum inhibitory and bacterial concentrations of theaflavin and synergistic combinations with epicatechin and quercetin against clinical isolates of Stenotrophomonas Maltophilia

, 2012
Stenotrophomonas maltophilia is an important nosocomial pathogen with intrinsic resistance to multiple antibiotics. Previous investigations have shown flavanols from black tea to possess antibacterial activity.
Betts, Jonathan, Haswell, Stephen, Kelly, Stephen, Murphy, Christine   +3 more
core  

Antibacterial effects of ethanolic extract of walnut leaves (Juglans regia) on propionibacterium acnes [PDF]

, 2010
Background and Objective: Acne is one of the medical problems and propionibacterium acnes is the pathogenic agent that has received a considerable attention. Different parts of Juglans regia have been shown to have antibacterial activity on many bacteria.
Rafieian-Kopaei, Mahmoud., Sharafati Chaleshtori, Farhad., Sharafati Chaleshtori, Reza.   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Investigations of Antibacterial Activity of Methanol and Aqueous Ex-tracts of the Body Wall of Sea Cucumber Holothuria leucospilota on some Human Pathogenic Bacteria

پزشکی بالینی ابن سینا, 2016
Introduction & Objective: Holothuria leucospilota, sea cucumber, is a species of the Phylum Echinodermata. Sea cucumbers have the most natural products with biological activity.
M. Nazemi, Y. Moradi, M. Gozari, F. Legzaee, M. Karimpour   +4 more
doaj