Results 51 to 60 of about 11,714 (256)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The In vitro Study of Antimicrobial Effect of Teucrium polium Extract on Infectious Microorganisms

پزشکی بالینی ابن سینا, 2014
Introduction & Objective: Teucrium polium belonging to Lamiaceae family has been widely used in traditional medicine for treatment of diseases. Regarding the existence of the active biological compounds in this plant, it seems that this plant has ...
Farideh Tabatabaei Yazdi, Behruz Alizadeh Behbahani, Maryam Heidari Sureshjani, Seyyed Ali Mortazavi   +3 more
doaj  

Determining the Minimum Inhibitory Concentration of Bacteriophages: Potential Advantages

Advances in Microbiology, 2013
The minimum inhibitory concentration (MIC) is the concentration at which an antibacterial agent experiences the complete inhibition of organism growth. Bacteriophages represent a rich and unique resource of anti-infectives to counter the growing world-wide problem of antibiotic resistance.
Pallavi Ravinder, Nethravathi Poonacha, Aradhana Vipra, Bharathi Sriram, Srividya Narayanamurthy Desai, Panchali Roy, Raghu Patil Junjappa, Sriram Padmanabhan   +7 more
openaire   +3 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

The effect of walnut thin shell extract on the growth of Penicillium species [PDF]

International Journal of Biomedicine and Public Health, 2018
Introduction: Fungi broadly exist in the environment. Growing interest for natural and safe additives as well as concerns about synthetic fungicide have led to development of various fungicides. This study aimed to examine the effect of walnut thin shell
Ehsan Haghi, Fariba Razeghi, Fereshteh Ahmadi, Nabi Shariati Far   +3 more
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

A study of In vitro antifungal susceptibility patterns of dermatophytic fungi at a tertiary care center in Western India

Indian Journal of Dermatology, 2019
Background: Recent years have seen an alarming rise in the prevalence of recalcitrant and relapsing dermatophyte infections in India associated with lack of clinical response to standard antifungal regimens. Aims and Objectives: A study was undertaken to
Shital Poojary, Autar Miskeen, Jimish Bagadia, Saurabh Jaiswal, Priya Uppuluri   +4 more
doaj   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Biosynthesis of Silver Nanoparticles Using Bacteria Isolates from Wastewater

Medical Laboratory Journal, 2017
Background and Objectives: Development of ecofriendly processes for the synthesis of metal nanoparticles is of great importance in the field of nanotechnology.
Shima Kazemi, Monir Doudi, Gholm Reza Amiri   +2 more
doaj  

A Comparison of the Minimum Inhibitory Concentrations of Sisomicin and of Fourteen Other Antibiotics

Journal of International Medical Research, 1978
The activities of sisomicin and of fourteen other antibiotics have been compared for their inhibitory activity on all the different strains of bacteria isolated from a 3,000 bed hospital. The antibiotic sensitivity tests were performed in liquid medium and expressed as minimum inhibitory concentrations.
F Romano, A Turano, E Pitzus, P Ghinelli, G P Cadenelli   +4 more
openaire   +3 more sources