Results 71 to 80 of about 12,527 (214)

Comparing the Minimum Inhibitory Concentrations and Minimum Fungicidal Concentrations of Antifungal Drugs in Microsporum canis.

Medical mycology journal
To assess the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) of itraconazole (ITCZ), terbinafine (TBF), and miconazole (MCZ) in eight isolates of Microsporum canis. The MICs in the eight tested strains were < 0.03 mg/L for TBF, < 0.03 to 0.125 mg/L for ITCZ, and 1 to 4 mg/L for MCZ.
Nojo, Honoka, Watanabe, Akira, Makimura, Koichi, Kano, Rui   +3 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Antibacterial Potential of Essential Oils Against Ground Beef Isolates

Revista Segurança Alimentar e Nutricional, 2017
The objective of this study was to evaluate the antibacterial activity of different EOs against Escherichia coli, Salmonella spp., and coagulase-positive staphylococcus isolated from ground beef. The EOs had values varying from 0.78μl/mL to 100μl/mL, and
Lisiane Martins Volcão, Juliana de Lima Marques, Lucas Moreira dos Santos, Suzane Olachea Allend, Kamila da Cunha Furtado, Rosana Serpa, Gladis Aver Ribeiro   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Correlation between corneal concentration and minimum inhibitory concentration of antifungals in patients undergoing therapeutic keratoplasty for fungal keratitis

Indian Journal of Ophthalmology
Objectives: To correlate corneal concentration and minimum inhibitory concentration (MIC) of antifungal drugs in patients undergoing therapeutic penetrating keratoplasty (TPK) for fungal keratitis.
Vinay Patil, Aafreen Bari, Prafulla Kumar Maharana, Nishat Ahmed, Ritu Nagpal, Rajesh Sinha, Tushar Agarwal, Namrata Sharma, T Velpandian, Jeewan Singh Titiyal   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Discordance in genotypic and phenotypic drug susceptibility results: time to reconsider critical concentration of rifampicin

Microbiology Spectrum
The objective of this study is to correlate rpoB mutations found on the new-generation sequencing (NGS) in Mycobacterium tuberculosis (MTB) isolates with minimum inhibitory concentrations (MICs) to the rifampicin (RIF). We assessed the minimum inhibitory
Arti Shrivas, Sarman Singh, Jitendra Singh, Prem Shankar, Payal Soni, Syed Beenish Rufai, Anand Maurya, Shashank Purwar   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The minimum inhibitory concentration of different candidal disinfecting agents

Saudi Journal of Medicine and Medical Sciences, 2015
Purpose: Despite the availability of a large number of commercial denture cleansing products, only a few are used by wearers of dentures. This may be due to negligence on the part of the wearers of dentures and or the high cost of the products.
Aiman A Ali, Fahad A Al Harbi
doaj   +1 more source