Results 91 to 100 of about 332,055 (262)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

On the Rank, Order and Class of Algebraic Minimum Curves [PDF]

Transactions of the American Mathematical Society, 1902
The equations of all analytic minimum curves may be written in terms of a complex parameter s and an arbitrary analytic function F(s). The curve will be algebraic when and only when F(s) is an algebraic function, and then the rank, order and class of the curve can be easily expressed as the orders of three functions, #(s), 4(s) and X(s), (see ?
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Image Classification Using Low-Rank Regularized Extreme Learning Machine

IEEE Access, 2019
Extreme learning machine (ELM), a least-square-based learning algorithm, is a competitive machine learning method and provides efficient unified learning solutions for the applications of classification and regression.
Qin Li, Yang Liu, Shujian Wang, Quanxue Gao, Xinbo Gao   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Clutter rank estimation for the multistage Wiener filter

IET Radar, Sonar & Navigation
In airborne radar, reduced rank detection techniques are used when there are insufficient samples available for fully adaptive processing. This is the case in maritime radar, where the data can be both non‐stationary and non‐homogeneous.
Rachel Gray, Elias Aboutanios, Luke Rosenberg, Josef Zuk   +3 more
doaj   +1 more source

The use of quantile trees in the prediction of the diameter distribution of a stand

Silva Fennica, 2006
This study deals with the prediction of the basal area diameter distribution of a stand without using a complete sample of diameters from the target stand.
Mehtätalo, Lauri, Maltamo, Matti, Kangas, Annika   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source