Results 131 to 140 of about 2,717,266 (303)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Spatial Downscaling of Daily Temperature Minima Using Machine Learning Methods and Application to Frost Forecasting in Two Alpine Valleys

Atmosphere
This study examines the performance of three machine learning models—namely, Artificial Neural Network (ANN), Random Forest (RF), and Convolutional Neural Network (CNN)—for spatial downscaling of seasonal forecasts of daily minimum temperature from 12 km
Sudheer Bhakare, Michael Matiu, Alice Crespi, Dino Zardi   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Minimum ignition temperature of hybrid mixtures

Chemical Engineering Transactions, 2019
The minimum ignition temperature is an important safety value for handling gases, liquids and dust. The European regulation only provides standards to measure single substances and single-phase values.
Dieter Gabel, Ulrich Krause
doaj   +1 more source

Enhanced electrical resistivity before N\'eel order in the metals, RCuAs$_2$ (R= Sm, Gd, Tb and Dy

, 2003
We report an unusual temperature (T) dependent electrical resistivity($\rho$) behavior in a class of ternary intermetallic compounds of the type RCuAs$_2$ (R= Rare-earths).
E. V. Sampathkumaran, E. V. Sampathkumaran, E. V. Sampathkumaran, J. P. F. Jemetio, J.-P. F. Jemetio, Kartik K. Iyer, Kausik Sengupta, M. B. Maple, N. F. Mott, R. Mallik, S. Legwold, S. Rayaprol, S. K. Ma, See, for review, U. Rauschwalbe, Th. Doert, Y. Shapira   +15 more
core   +1 more source

Nowcasting daily minimum air and grass temperature [PDF]

International Journal of Biometeorology, 2015
Site-specific and accurate prediction of daily minimum air and grass temperatures, made available online several hours before their occurrence, would be of significant benefit to several economic sectors and for planning human activities. Site-specific and reasonably accurate nowcasts of daily minimum temperature several hours before its occurrence ...
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

What Is the Rain‐Fed Wheat and Barley Yield Response to Rainfall Distribution Index in a Cold Sub‐Humid Region?

Meteorological Applications
Rain‐fed crop yields are heavily influenced by seasonal rainfall patterns and temperature, particularly during vegetative and reproductive growth stages.
Fatemeh Razzaghi, Nahid Pourabdollah, Ali Reza Sepaskhah   +2 more
doaj   +1 more source

A Model for Nighttime Minimum Temperatures

Journal of Climate, 2014
AbstractThe southwestern United States has experienced some of the most important increases in nighttime minimum temperatures over the last 60 yr, and climate models are projecting more of the same to the end of the century. As climate, geography, and population density vary considerably over the area, very diverse extreme temperature levels and ...
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source