Results 121 to 130 of about 605,028 (307)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Incremental Word Learning Using Large-Margin Discriminative Training and Variance Floor Estimation

, 2010
Ayllon Clemente I, Heckmann M, Denecke A, Wrede B, Görick C. Incremental Word Learning Using Large-Margin Discriminative Training and Variance Floor Estimation.
Ayllon Clemente, Irene, Heckmann, Martin, Wrede, Britta ; https://orcid.org/, Görick, Christian, Denecke, Alexander   +4 more
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Optimal minimum variance-entropy control of tumour growth processes based on the Fokker-Planck equation. [PDF]

IET Syst Biol, 2020
Sargolzaei M, Latif-Shabgahi G, Afshar M.   +2 more
europepmc   +1 more source

The effect of realised volatility on stock returns risk estimates [PDF]

, 2007
In this paper, we estimate minimum capital risk requirements for short, long positions and three investment horizons, using the traditional GARCH model and two other GARCH-type models that incorporate the possibility of asymmetric responses of ...
Grané, Aurea, Veiga, Helena, Grané Chávez, Aurea   +2 more
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Relative Entropy and Minimum-Variance Pricing Kernel in Asset Pricing Model Evaluation. [PDF]

Entropy (Basel), 2020
Rojo-Suárez J, Alonso-Conde AB.
europepmc   +1 more source

Empirical Minimum-Variance Hedge (The) [PDF]

Decision making under unknown true parameters (estimation risk) is discussed along with Bayes' and parameter certainty equivalent (PCE) criteria. Bayes' criterion incorporates estimation risk in a manner consistent with expected utility maximization. The
Hayes, Dermot J., Lence, Sergio H.
core  

Minimum-Variance Stock Picking -A Shift in Preferences for Minimum-Variance Portfolio Constituents

, 2020
Minimum-variance (equity) portfolio selection is increasingly popular among investors. We study a broad set of 63 different, commonly used approaches to build long-only minimum-variance portfolios among US as well as European stocks.
Thomas Dangl, Michael Kashofer
core