Results 101 to 110 of about 605,028 (307)

Mean-variance inefficiency of CRRA and CARA utility functions for portfolio selection in defined contribution pension schemes [PDF]

open access: yes
We consider the portfolio selection problem in the accumulation phase of a defined contribution pension scheme in continuous time, and compare the mean-variance and the expected utility maximization approaches.
Elena Vigna
core  

Minimum variance quadratic unbiased estimation of variance components

open access: yes, 1971
The variance of a quadratic function of the random variables in a linear model is minimized to obtain locally best unbiased estimators (MIVQUE) of variance components.
Rao, C. Radhakrishna   +1 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

On efficiency of mean-variance based portfolio selection in DC pension schemes [PDF]

open access: yes
We consider the portfolio selection problem in the accumulation phase of a defined contribution (DC) pension scheme. We solve the mean-variance portfolio selection problem using the embedding technique pioneered by Zhou and Li (2000) and show that it is ...
Elena Vigna
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Lamb Wave-Minimum Sampling Variance Particle Filter-Based Fatigue Crack Prognosis

open access: yesSensors, 2019
Fatigue cracks are one of the common failure types of key aircraft components, and they are the focus of prognostics and health management (PHM) systems. Monitoring and prediction of fatigue cracks show great application potential and economic benefit in
Weibo Yang, Peiwei Gao
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

An analytical investigation of estimators for expected asset returns from the perspective of optimal asset allocation [PDF]

open access: yes
In the present work I derive the risk functions of 5 standard estimators for expected asset returns which are frequently advocated in the literature, viz the sample mean vector, the James-Stein and Bayes-Stein estimator, the minimum-variance estimator ...
Frahm, Gabriel
core  

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