Results 111 to 120 of about 1,308,568 (298)

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Agile in Public Administration: Oxymoron or reality? An experience report [PDF]

, 2013
In the last 10 years, Agile methods and practices have emerged as an alternative for software development. Different "flavors" of Agile have appeared ranging from project management to tests organization. These approaches have being gaining popularity
Escalona Cuaresma, María José, Mejías Risoto, Manuel, Sedeño López, Jorge, Torrecilla Salinas, Carlos Joaquín   +3 more
core  

Spin Hall Nano‐Antenna

Advanced Science, EarlyView.
ABSTRACT The spin Hall effect is a well‐known phenomenon in spintronics that has found numerous applications in digital electronics (memory and logic), but relatively few in analog electronics. Practically the only analog application in widespread use is the spin Hall nano‐oscillator (SHNO) that delivers a high frequency alternating current or voltage ...
Raisa Fabiha, Pratap Kumar Pal, Michael Suche, Amrit Kumar Mondal, Erdem Topsakal, Anjan Barman, Supriyo Bandyopadhyay   +6 more
wiley   +1 more source

STATUTUL PROCURORULUI ÎN ROMÂNIA

EIRP Proceedings, 2007
The current status of the prosecutor n Romania is without doubt a composite one: the status of amagistrate and of an executive agent at the same time.
Victor Alistar
doaj  

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

ASPECTS OF DECISIONAL TRANSPARENCY WITHIN THE PREFECT’S INSTITUTION IN ROMANIA AS A CHALLENGE IN A EUROPEAN UNION GOVERNENCE [PDF]

Annals of the University of Oradea: Economic Science, 2016
The analysis of the concept of 'international transparency' will show that there is a major interest in making public the information related to public administration or public sector.
TIMOFTE Claudia Simona
doaj  

The Role of Ideas in the Emergence of Convergent Higher Education Policies in Europe: The Case of France. CES Working Paper, no. 73 [PDF]

, 2000
How do ideas influence public policy ? French higher education is a good case in point. It seems reasonable to think that the recent evolution French universities underwent resulted from the diffusion of the convergent discourse held by most European ...
Musselin, Christine.
core  

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Lawsuits against the Brazilian Unified Health System regarding Bladder/Ureteral Cancer

Brazilian Journal of Oncology
Objective To evaluate the technical notes (TNs) issued by the Center for Technical Support of the Judiciary (Núcleo de Apoio Técnico do Poder Judiciário, NAT-Jus, in Portuguese) of the Brazilian Ministry of Justice regarding lawsuits against ...
Fernando Korkes, Mariana Avelar da Silveira, Flavio Tocci, Carlos Pedrotti, Vanessa Damazio Teich, Luciana Holz Camargo de-Barros, Sidney Glinas   +6 more
doaj   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source