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Minor histocompatibility antigens
Current Opinion in Immunology, 1997The existence of transplantation antigens, in addition to those encoded by genes in the MHC, has been known for over half a century. The molecular identification of these additional minor histocompatibility (H) antigens lagged behind that of their MHC counterparts, largely because minor H antigens are recognised by T cells and not by antibodies. In the
Simpson, E, Roopenian, D C
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H-Y as a minor histocompatibility antigen in kidney transplantation: a retrospective cohort study
Lancet, The, 2008 BACKGROUND: In haematopoietic stem-cell transplantation, male recipients of female grafts have an increased risk of graft-versus-host disease and female recipients have both an increased risk of rejection of male grafts and of specific T-cell and ...
Alois Gratwohl, Bernd Döhler
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Tolerance to minor histocompatibility antigens
Immunology Letters, 1988A neonatal tolerance model employing fully allogeneic lymphoid cells as tolerogen was used in an investigation of tolerance to self and donor minor histocompatibility antigens (miHA). Tolerance was assessed by skin grafting and subsequently by the generation of cytotoxic T lymphocytes. Two strain combinations were investigated. In the first, BALB/c-B10,
L S, Rayfield, L, Brent, K, Samuel
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Minor histocompatibility antigens
Immunology Letters, 1991Immune responses against foreign tissue or organs can be directed against alloantigenic differences between donor and host encoded by genes of the major histocompatibility complex (MHC; HLA in man and H-2 in mouse). However, when MHC antigens are matched, as in HLA-identical siblings, or between different mouse strains sharing the same H-2 haplotype ...
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The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism
Science, 1998 The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen-identical bone marrow transplantation.
Joke M M Den Haan +2 more
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Minor Histocompatibility Antigens in GVL
2000In syngeneic bone marrow transplantation (BMT) and in recipients of autologous BMT, relapse rates are high. No MHC or minor histocompatibility antigen (mHag) disparities exist and thus no alloreactivities can be induced. This is clearly different in allogeneic BMT, where the relapse rates are significantly lower and a relationship is seen between the ...
Mutis, Tuna, Goulmy, Els
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Minor Histocompatibility Antigens and Marrow Transplantation
New England Journal of Medicine, 1996Acute graft-versus-host disease (GVHD) and graft rejection are the principal obstacles to successful allogeneic bone marrow transplantation.
N A, Kernan, B, Dupont
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Major vs minor histocompatibility antigens
Blood, 2017In this issue of Blood, Martin et al found that the number of minor histocompatibility antigen mismatches doubles in unrelated vs sibling HLA-matched transplants, but has less impact on graft-versus-host disease (GVHD) than mismatching at HLA-DP ...
Denis Claude Roy, Claude Perreault
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Minor histocompatibility antigens – big in tumour therapy
Trends in Immunology, 2004Technical advances combined with the deciphering of the human genome have facilitated the identification of the molecular nature of human minor histocompatibility (H) antigens. To date, it is believed that minor H antigens result from just any polymorphic protein, regardless of their functional properties.
Spierings, E. +2 more
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Presentation and recognition of major and minor histocompatibility antigens
Transplant Immunology, 1994The structural basis of allorecognition is heterogeneous. For minor histocompatibility antigen-specific T cells and for a minority of anti-MHC T cells (indirect allorecognition), the allogeneic molecule acts as any other protein, and is processed and presented as a peptide in the context of self MHC.
A N, Warrens, G, Lombardi, R I, Lechler
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