Results 1 to 10 of about 96,199 (216)

Alemtuzumab in allogeneic hematopoetic stem cell transplantation [PDF]

Expert Opinion on Biological Therapy, 2011
With the use of reduced-intensity conditioning (RIC), early toxicity of allogeneic stem cell transplantation (SCT) has been much reduced. Graft-versus-host disease (GvHD) causes morbidities and mortality. Alemtuzumab is a mAb directed against CD52. When administered prior to transplant, it leads to T-cell depletion.
Koen Van Besien, Xavier Poire
exaly   +3 more sources

Early relapse prediction after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia (ALL) using lineage‐specific chimerism analysis

eJHaem, 2022
Relapse is a major cause of treatment failure after hematopoietic stem cell transplantation (HSCT) for acute leukemia. Here, we report a monocentric retrospective study of all HSCTs for B cell acute lymphoblastic leukemia (ALL) performed during the years
Hannes Lindahl, Davide Valentini, Sofie Vonlanthen, Mikael Sundin, Andreas T. Björklund, Stephan Mielke, Dan Hauzenberger   +6 more
doaj   +1 more source

Allogeneic Stem Cell Transplantation in Myelofibrosis [PDF]

Biology of Blood and Marrow Transplantation, 2017
Myeloproliferative neoplasm (MPN) is a category in the World Health Organization classification of myeloid tumors. BCR-ABL1-negative MPN is a subcategory that includes primary myelofibrosis (MF), post-essential thrombocythemia MF, and post-polycythemia vera MF. These disorders are characterized by stem cell-derived clonal myeloproliferation. Clinically,
Tania, Jain, Ruben A, Mesa, Jeanne M, Palmer   +2 more
openaire   +2 more sources

The Importance of Secretor-Status in Norovirus Infection Following Allogeneic Hematopoietic Stem Cell Transplantation

Viruses, 2022
Background. Human secretor-status is a strong susceptibility factor for norovirus infection in immunocompetent people. The predominant norovirus genotype GII.4 almost exclusively infects secretors and is also associated with more severe symptoms. However,
Lisa Swartling, Elda Sparrelid, Per Ljungman, Ksenia Boriskina, Davide Valentini, Lennart Svensson, Johan Nordgren   +6 more
doaj   +1 more source

A study on some factors affecting CMV reactivation in allogeneic hematopoietic stem cells transplantation [PDF]

Egyptian Journal of Cancer and Biomedical Research, 2021
Background: In developing countries, cytomegalovirus (CMV) seropositivity has been widely propagated. Following hematopoeitic stem cell transplantation, the apparent risk of CMV reactivation increases.
Metwally Metwally, Mohamed El-Shanshory, Nanis Allam, Raafat Soliman, Hamdy Abu Ouf   +4 more
doaj   +1 more source

Donor lymphocyte count and thymic activity predict lymphocyte recovery and outcomes after matched-sibling hematopoietic stem cell transplant

Haematologica, 2013
Delayed immune recovery is a characteristic feature of allogeneic hematopoietic stem cell transplantation in adult recipients. Although recipient thymic T-cell neogenesis contributes to T-cell regeneration after transplantation, thymic recovery in the ...
Zachariah McIver, Jan Joseph Melenhorst, Colin Wu, Andrew Grim, Sawa Ito, Irene Cho, Nancy Hensel, Minoo Battiwalla, Austin John Barrett   +8 more
doaj   +1 more source

A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation

Haematologica, 2016
Improvement of graft-versus-host disease prophylaxis remains an important goal in allogeneic hematopoietic stem cell transplantation. Based on reports of possibly preferential properties of sirolimus, we compared the standard regimen of cyclosporine and ...
Johan Törlén, Olle Ringdén, Karin Garming-Legert, Per Ljungman, Jacek Winiarski, Kari Remes, Maija Itälä-Remes, Mats Remberger, Jonas Mattsson   +8 more
doaj   +1 more source

The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation

Iraqi Journal of Hematology, 2022
BACKGROUND: In allogeneic stem cell transplantation, donor and recipient HLA tissue compatibility is essential for the success of stem cell transplantation. HLA tissue compatibility percentage is the most important parameter that increases the success of
Ahmet Kaya, Mehmet Ali Erkurt, İrfan Kuku, Emin Kaya, İlhami Berber, Soykan Biçim, Emine Hidayet, Fatma Hilal Yağin, Ahmet Sarıcı   +8 more
doaj   +1 more source

Allogeneic stem cell transplantation for neuroblastoma [PDF]

The Korean Journal of Hematology, 2012
Neuroblastoma (NB) is the most common extracranial solid tumor in children. Although the prognosis of lowand intermediate-risk NB with conventional treatment modalities is excellent, the prognosis of high-risk NB with conventional treatment alone is very poor. The current standard treatment for high-risk NB consists of induction treatment (conventional
openaire   +2 more sources

Donor Cell Composition and Reactivity Predict Risk of Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Journal of Immunology Research, 2016
Background. Graft-versus-host disease (GVHD) is a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). We designed a functional assay for assessment of individual risk for acute GVHD. Study Design and Methods.
Darius Sairafi, Arwen Stikvoort, Jens Gertow, Jonas Mattsson, Michael Uhlin   +4 more
doaj   +1 more source