Results 11 to 20 of about 72,842 (263)

Early relapse prediction after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia (ALL) using lineage‐specific chimerism analysis

eJHaem, 2022
Relapse is a major cause of treatment failure after hematopoietic stem cell transplantation (HSCT) for acute leukemia. Here, we report a monocentric retrospective study of all HSCTs for B cell acute lymphoblastic leukemia (ALL) performed during the years
Hannes Lindahl, Davide Valentini, Sofie Vonlanthen, Mikael Sundin, Andreas T. Björklund, Stephan Mielke, Dan Hauzenberger   +6 more
doaj   +1 more source

The Importance of Secretor-Status in Norovirus Infection Following Allogeneic Hematopoietic Stem Cell Transplantation

Viruses, 2022
Background. Human secretor-status is a strong susceptibility factor for norovirus infection in immunocompetent people. The predominant norovirus genotype GII.4 almost exclusively infects secretors and is also associated with more severe symptoms. However,
Lisa Swartling, Elda Sparrelid, Per Ljungman, Ksenia Boriskina, Davide Valentini, Lennart Svensson, Johan Nordgren   +6 more
doaj   +1 more source

A study on some factors affecting CMV reactivation in allogeneic hematopoietic stem cells transplantation [PDF]

Egyptian Journal of Cancer and Biomedical Research, 2021
Background: In developing countries, cytomegalovirus (CMV) seropositivity has been widely propagated. Following hematopoeitic stem cell transplantation, the apparent risk of CMV reactivation increases.
Metwally Metwally, Mohamed El-Shanshory, Nanis Allam, Raafat Soliman, Hamdy Abu Ouf   +4 more
doaj   +1 more source

Donor lymphocyte count and thymic activity predict lymphocyte recovery and outcomes after matched-sibling hematopoietic stem cell transplant

Haematologica, 2013
Delayed immune recovery is a characteristic feature of allogeneic hematopoietic stem cell transplantation in adult recipients. Although recipient thymic T-cell neogenesis contributes to T-cell regeneration after transplantation, thymic recovery in the ...
Zachariah McIver, Jan Joseph Melenhorst, Colin Wu, Andrew Grim, Sawa Ito, Irene Cho, Nancy Hensel, Minoo Battiwalla, Austin John Barrett   +8 more
doaj   +1 more source

A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation

Haematologica, 2016
Improvement of graft-versus-host disease prophylaxis remains an important goal in allogeneic hematopoietic stem cell transplantation. Based on reports of possibly preferential properties of sirolimus, we compared the standard regimen of cyclosporine and ...
Johan Törlén, Olle Ringdén, Karin Garming-Legert, Per Ljungman, Jacek Winiarski, Kari Remes, Maija Itälä-Remes, Mats Remberger, Jonas Mattsson   +8 more
doaj   +1 more source

The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation

Iraqi Journal of Hematology, 2022
BACKGROUND: In allogeneic stem cell transplantation, donor and recipient HLA tissue compatibility is essential for the success of stem cell transplantation. HLA tissue compatibility percentage is the most important parameter that increases the success of
Ahmet Kaya, Mehmet Ali Erkurt, İrfan Kuku, Emin Kaya, İlhami Berber, Soykan Biçim, Emine Hidayet, Fatma Hilal Yağin, Ahmet Sarıcı   +8 more
doaj   +1 more source

Donor Cell Composition and Reactivity Predict Risk of Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Journal of Immunology Research, 2016
Background. Graft-versus-host disease (GVHD) is a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). We designed a functional assay for assessment of individual risk for acute GVHD. Study Design and Methods.
Darius Sairafi, Arwen Stikvoort, Jens Gertow, Jonas Mattsson, Michael Uhlin   +4 more
doaj   +1 more source

Respiratory Virus Infections in Hematopoietic Cell Transplant Recipients

Frontiers in Microbiology, 2019
Highly immunocompromised pediatric and adult hematopoietic cell transplant (HCT) recipients frequently experience respiratory infections caused by viruses that are less virulent in immunocompetent individuals. Most of these infections, with the exception
Cécile Pochon, Sebastian Voigt, Sebastian Voigt   +2 more
doaj   +1 more source

Mycobacterium tuberculosis-specific and MHC class I-restricted CD8+ T-cells exhibit a stem cell precursor-like phenotype in patients with active pulmonary tuberculosis

International Journal of Infectious Diseases, 2015
The nature and longevity of the T-cell response directed against Mycobacterium tuberculosis (MTB) are important for effective pathogen containment. We analyzed ex vivo the nature of MTB antigen-specific T-cell responses directed against the MTB secreted ...
Rebecca Axelsson-Robertson, Ji Hyeon Ju, Ho-Youn Kim, Alimuddin Zumla, Markus Maeurer   +4 more
doaj   +1 more source

KRAS RENAISSANCE(S) in Tumor Infiltrating B Cells in Pancreatic Cancer

Frontiers in Oncology, 2018
KRAS is a driver mutation for malignant transformation. It is found in 30% of all cancers and in 90% of pancreatic cancers. The identification of small molecules selectively inhibiting KRAS mutants has been challenging, yet mutant KRAS has recently been ...
Qingda Meng, Davide Valentini, Martin Rao, Markus Maeurer, Markus Maeurer   +4 more
doaj   +1 more source