Results 31 to 40 of about 96,199 (216)

CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation

Haematologica, 2008
Background Very little is known about the number and function of immunosuppressive CD4+CD25+FOXP3+ T regulatory cells (Treg) in the human bone marrow and it is unclear whether bone marrow-residing Treg are capable of regenerating following allogeneic ...
Djordje Atanackovic, Yanran Cao, Tim Luetkens, Jens Panse, Christiane Faltz, Julia Arfsten, Katrin Bartels, Christine Wolschke, Thomas Eiermann, Axel R. Zander, Boris Fehse, Carsten Bokemeyer, Nicolaus Kroger   +12 more
doaj   +1 more source

Allogeneic Stem Cell Transplantation for Myelofibrosis in 2012 [PDF]

British Journal of Haematology, 2012
SummaryMyelofibrosis (MF) is a heterogeneous disease for which long‐term, effective medical therapeutic options are currently limited. The role of allogeneic haematopoietic stem cell transplant (AHSCT) in this population, many of whom are elderly, often provides a challenge with regard to the identification of suitable candidates, timing of ...
McLornan, Donal, Mead, Adam J., Jackson, Graham, Harrison, Claire   +3 more
openaire   +5 more sources

Evidence Map for the Indirect Effects of CMV Infection on Patients with Allogeneic Hematopoietic Stem Cell transplantation [PDF]

, 2022
Xiaojin Wu, Xiao Ma, Tiemei Song, Jie Liu, Yi Sun, Depei Wu   +5 more
openalex   +1 more source

Allogeneic stem cell transplantation for thalassemia major

Haematologica, 2008
Allogeneic hemopoietic stem cell (HSC) transplantation in thalassemia major has been a cornerstone of the development of cell-based therapies[1][1] and a matter of passionate debate during the ‘80s and early ‘90s.[2][2] The aim of HSC transplantation in thalassemia is to replace the ...
Emanuele Angelucci, Donatella Baronciani
openaire   +3 more sources

Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation [PDF]

Journal of Hematotherapy & Stem Cell Research, 2002
Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) effect.
Baron, Frédéric, Beguin, Yves
openaire   +3 more sources

Allogeneic Stem Cell Transplantation for Aplastic Anemia

Biology of Blood and Marrow Transplantation, 2007
Aplastic anemia encompasses a heterogeneous group of diseases with distinct pathophysiologies and a common clinical endpoint of marrow failure. Patients with severe aplastic anemia can be treated with immunosuppressive therapy (IST) or hematopoietic stem cell transplantation (HSCT).
Armand, Philippe, Antin, Joseph H.
openaire   +2 more sources

Allogeneic stem cell transplantation in follicular lymphoma [PDF]

Best Practice & Research Clinical Haematology, 2011
Myeloablative allogeneic transplantation in follicular lymphoma has been found to be particularly effective in patients with relapsed disease and an inadequate bone marrow reserve or massive bone marrow involvement. Allogeneic transplantation carries the promise of long-term disease control by graft-versus-lymphoma immunity but is associated with a 30%-
openaire   +2 more sources

Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro

Molecular Therapy: Nucleic Acids
Antisense oligonucleotides (ASOs), including splice-switching oligonucleotides (SSOs), are promising therapeutic approaches for targeting genetic defects.
H. Yesid Estupiñán, Tom Baladi, Samantha Roudi, Michael J. Munson, Jeremy Bost, Oskar Gustafsson, Daniel Velásquez-Ramírez, Deepak Kumar Bhatt, Daniel Hagey, Dennis Hekman, Shalini Andersson, Samir EL Andaloussi, Anders Dahlén   +12 more
doaj   +1 more source

Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literature

Experimental Hematology & Oncology, 2017
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been considered as a valuable approach in treatment of numerous malignant and none malignant hematologic disorders. However, relapse and poor graft function (PGF) after allo-SCT remain to
Saeed Mohammadi, Amir Hossein Norooznezhad, Ashraf Malek Mohammadi, Hajar Nasiri, Mohsen Nikbakht, Najmaldin Saki, Mohammad Vaezi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh   +8 more
doaj   +1 more source

Autologous Graft-versus-Tumor Effect: Reality or Fiction?

Advances in Hematology, 2016
In contrast to allogeneic hematopoietic stem cell transplantation, the current dogma is not an evidence of graft-versus-tumor effect in autologous hematopoietic stem cell transplantation; thus, it is assumed that autologous hematopoietic stem cell ...
Luis F. Porrata
doaj   +1 more source