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Immunodominant minor histocompatibility antigens: the major ones
Immunology Today, 1998Abstract Minor histocompatibility antigens (MiHAs) are extremely numerous—possibly up to 720 in mice—and have been regarded as an `immunogenetic nightmare' in transplantation. Here, Claude Perreault, Denis Roy and Claudette Fortin summarize evidence showing that most anti-MiHA T-cell responses are oligoclonal, being restricted to several dominant ...
C, Perreault, D C, Roy, C, Fortin
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Much ado about minor histocompatibility antigens
Immunology Today, 1998Abstract Current knowledge of histocompatibility (H) loci located outside of the major histocompatibility complex - i.e. those encoding the so-called minor H antigens - was surveyed at a recent meeting ∗ ∗The 1st International Symposium on Minor Histocompatibility Antigens was held at Bar Harbor, ME, USA, on 14–17 September 1997..
Simpson, E, Roopenian, D, Goulmy, E
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Molecular Typing Methods for Minor Histocompatibility Antigens
2007Minor histocompatibility (H) antigens crucially affect the outcome of human leukocyte antigen-matched allogeneic stem cell transplantation. The number of molecularly identified minor H antigens is rapidly increasing. In parallel, clinical implementation of minor H antigens for immunotherapy has gained significant interest.
Eric, Spierings, Els, Goulmy
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Minor histocompatibility antigens: past, present, and future
Tissue Antigens, 2014AbstractMinor histocompatibility (H) antigens are key molecules driving allo‐immune responses in both graft‐versus‐host‐disease (GvHD) and in graft‐versus‐leukemia (GvL) reactivity in human leukocyte antigen (HLA)‐matched hematopoietic stem‐cell transplantation (HSCT).
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Minor Histocompatibility Antigens
The Cancer Journal, 2004Minor histocompatibility antigens have to be considered as key molecules in the stem cell-based immunotherapy of malignancies. Allogeneic stem cell transplantation (SCT) is a well-established and effective therapy for advanced hematologic malignancies.
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Molecular Typing Methods for Minor Histocompatibility Antigens
2013Minor histocompatibility (H) antigen mismatching leads to clinically relevant alloimmune reactivity. Depending on the tissue expression pattern of the involved minor H antigens, the immune response may either cause graft-versus-host disease and a graft-versus-tumor effect or lead to only a graft-versus-leukemia effect. Thus, identification of recipient-
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IMMUNE RESPONSE TO MINOR HISTOCOMPATIBILITY ANTIGENS
Transplantation, 1972L W, Schierman, R A, McBride
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