Results 31 to 40 of about 13,606 (275)

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano   +7 more
wiley   +1 more source

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack   +39 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

ANTI-LATIN TREATISE OF KIEV METROPOLITAN EPHREM(APPROXIMATELY1054/55-1061/62) INCLUDEDIN THE CONTENTS OF THE GREEK CANONICAL MISCELLANY VAT. GR. 828 [PDF]

open access: yesВестник Православного Свято-Тихоновского гуманитарного университета: Серия I. Богословие, философия, 2007
The article is the introduction to the publication of the Greek text of one of the first anti-Latin treatises by Greek Metropolitan Ephrem. The text of the article was published in Einantilateinischer Traktat des Kiever Metropoliten Ephraim // Fontes ...
I. S. CHICHUROV
doaj  

Le Clézio dans les forêts du Darién avec les Emberá : une réjuvénation poétique

open access: yesRelief: Revue Électronique de Littérature Francaise, 2022
Entre 1970 et 1974, l’écrivain J.M.G. Le Clézio se rend à plusieurs reprises, à raison de six à huit mois à chaque fois, dans les forêts du Darién, à la frontière entre le Panama et la Colombie.
Simon Levesque
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Posługiwanie biskupów, prezbiterów i diakonów w pismach Ojców Kościoła do V wieku

open access: yesVox Patrum, 2008
L’autore di quest’articolo richiama la nostra attenzione sulla terminologia che si usava per descrivere il servizio dei superiori istituiti dagli Apostoli nelle prime comunita cristiane: episcopi, presbiteri, diaconi, praepositi.
Czesław Krakowiak
doaj   +1 more source

The false Basel earthquake of May 12, 1021 [PDF]

open access: yes, 2018
The Basel (CH) area is a place with an increased seismic hazard. Consequently, it is essential to scrutinize a famous statement by Stumpf (Gemeiner loblicher Eydgnoschafft Stetten, Landen und Völckeren Chronikwirdiger thaaten beschreybung.
Fäh, Donat   +3 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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