Results 51 to 60 of about 2,068 (297)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Minores et livres de second rayon du XVIIIe siècle
, 1997 Goulemot Jean-Marie. Minores et livres de second rayon du XVIIIe siècle. In: Littératures classiques, n°31, automne 1997. Les « minores ». pp.
Goulemot, Jean-Marie
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Relief: Revue Électronique de Littérature Francaise, 2016 Un grand nombre d’écrivains portugais du dernier quart du XIXe siècle se réclamant du réalisme et du naturalisme, ou parfois certains de ses détracteurs, ont été des lecteurs de Flaubert en langue originale.
Luís Carlos Pimenta Gonçalves
doaj +5 more sources
Warszawskie Studia Teologiczne, 2019 The aim of this article is to analyse the events and documents of the Third Extraordinary General Assembly of the Synod of Bishops in 2014 and Fourteenth Ordinary General Assembly of the Synod of Bishops in 2015 in which Orthodox representatives also ...
Mihály Laurinyecz
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Studia w małopolskiej prowincji reformatów 1623-1865
Nasza Przeszłość, 1996 "Fratres minores strictioris observantiae", zwani reformatorami, przybyli do Polski w 1622 roku. W następnym roku utworzyli dwie kustodie: małopolską i wielkopolską, które w 1639 roku stały się prowincjami.
Henryk Błażkiewicz
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source