Results 71 to 80 of about 344 (255)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Studia w Małopolskiej Prowincji Reformatów 1623-1865. Część II.
Nasza Przeszłość, 1997 Fratres minores strictioris observantiae, zwani reformatami, organizowali studia we własnych domach zakonnych. Proces kształcenia rozpoczynał się od rocznego kursu przygotowawczego w ramach nowicjatu, a następnie kontynuowany był dwuletnim cyklem ...
Henryk Błażkiewicz
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Criticón, 2014 This article proposes a first approach to uses and meanings of scandal in the Golden Age, understood here as a specific type of heterodoxy, a form of dissent, one of the categories of propositiones damnabiles and hence an instrument of censorship that ...
María José Vega
doaj +1 more source
Orobancheingens (Orobanchaceae) - a poorly known species of the Greater Caucasus: taxonomic problems, distribution, hosts and habitats. [PDF]
PhytoKeys, 2022 Piwowarczyk R +3 more
europepmc +1 more source
Developing world: The minority minority [PDF]
Nature, 2015 Women are under-represented in physical sciences and in science in the developing world. Meet three who beat both sets of odds.
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source