Results 81 to 90 of about 344 (255)

Starania wrocławskiego Kościoła o uzyskanie swobody gospodarczej i sądowej na swych dobrach w I poł. XIII wieku – umowa z 1249 r.

open access: yesWrocławski Przegląd Teologiczny, 2013
By the end of the twelfth century the bishopric of Wrocław owned a lot of goods and become a major economic power, although it was not sovereign against princely power. On the lands, which were granted to the Bishop, were goods belonging to the prince or
Norbert Jerzak
doaj   +1 more source

The role of parental health beliefs in seeking an eye examination for their child. [PDF]

open access: yesBMC Ophthalmol, 2023
Masarwa D   +3 more
europepmc   +1 more source

Eragrostis minor subsp. minor

open access: yes, 2020
Published as part of Buldrini, Fabrizio, Gentilini, Matteo, Bruni, Cinzia, Santini, Claudio, Alessandrini, Alessandro & Bosi, Giovanna, 2020, Flora vascolare spontanea della città di Modena: analisi del centro storico, pp. 3-56 in Natural History Sciences 7 (1) on page 30, DOI: 10.4081/nhs.2020.443, http://zenodo.org/record ...
Buldrini, Fabrizio   +5 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Sjogren's syndrome combined with hypokalemic periodic paralysis (report of 2 cases with review of literature)

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2012
Objective To explore the early diagnosis and the therapy of Sjogren's syndrome combined with hypokalemic periodic paralysis. Methods Clinical data of 2 cases with Sjogren's syndrome and hypokalemic periodic paralysis were analyzed.
Xiao⁃juan CHENG   +2 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Nebrija y Maquiavelo ante un epigrama de Ausonio: paratexto y texto

open access: yesCuadernos de Filología Italiana, 2007
This article analyses the presence of an epigram by the poet Ausonio (IV AD) in Nebrija and in Machiavelli. The text by Ausonio, which in turn derived from a Greek text by Posidipo (III BC), must have been familiar to the European Humanism, since it ...
Cristina Barbolani
doaj  

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