Results 61 to 70 of about 344 (255)
"Bonshommes”, (the “new people”) and the pre-communal “conspiracy”. XI-XII Centuries
Montesquieu.it, 2018 In the crisis of the ancient political and ecclesiastical orders, which represented a true crisis in the legitimacy of the traditional authorities (Regnum e Sacerdotium fighting for universal supremacy), a profound and dramatic crisis for the medieval ...
Rita Bellelli
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Editorial: minor stroke is not minor
Stroke and Vascular Neurology, 2022 Xinyi Leng, David Wang
openaire +3 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Subscapularis minor – an analogue of the Teres minor?
Orthopaedics & Traumatology: Surgery & Research, 2013 The purpose of this study was to determine the role of the subscapularis (SSC) in forward flexion. We hypothesized that the inferior part of the SSC has a main role in the ability to preserve forward flexion in cases of anterosuperior rotator cuff tears.Active forward flexion of the shoulder was prospectively evaluated in patients presenting with Grade
Collin, Philippe +3 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Metateatralne elementy dramatów Witkacego
Pamiętnik Teatralny, 2016 Following in the footsteps of Alf Sjöberg and Krystyna Ruta-Rutkowska, the author of the article finds metatheatrical elements in the plays by Stanisław Ignacy Witkiewicz and by doing so casts doubt on the assertion made by Jan Błoński that it is ...
Przemysław Pawlak
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