Results 61 to 70 of about 743,702 (309)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Essence and Orientation of Educational Evaluation Reform in the New Era: What Kind of Educational Evaluation Do We Need in the New Era

Jiaoshi jiaoyu xuebao
The reform of educational evaluation in the new era means that educational evaluation has entered a new stage of development, which will demonstrate extraordinary value and strategic significance in politics, history, and reality. Understanding what kind
ZHU Dequan, CAO Dufan
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The democratic engagement of Britain's ethnic minorities [PDF]

, 2014
Democratic engagement is a multi-faceted phenomenon that embraces citizens' involvement with electoral politics, their participation in ‘conventional’ extra-parliamentary political activity, their satisfaction with democracy and trust in state ...
Almond Gabriel, Anthony Heath, Bowler Shaun, Cantle Ted, Cheung Sin Yi, David Sanders, Karn Valerie, Kornberg Alan, Leighley Jan E., Maria Sobolewska, Mueller Edward, Stephen D. Fisher, Verba Sidney   +12 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Values and Behavior Among Minorities in Southwest China: A Cross-Cultural Validation of the Refined Value Theory

Frontiers in Psychology, 2019
The minorities in Southwest China are characterized by a blend of diverse cultures. It is not clear how values predict behaviors in such a population.
Yanli Yang, Yanli Yang, Jia Zhou, Jia Zhou, Pan Feng, Guangyu Jiang, Yan Long, Yong Zheng, Yong Zheng   +8 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Rachel Humphris. 2019. Home-Land: Romanian Roma, Domestic Spaces and the State. Bristol: Bristol University Press, 240 p.

Martor, 2020
This volume by Rachel Humphris investigates the most intimate spheres of the social interaction with the street level bureaucracy of the state. The main actors involved in the interactions described and analyzed are the street level social “frontline ...
László Fosztó
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source