Results 61 to 70 of about 909,888 (305)

An integrated microbiome-drug interaction and bioinformatics approach identifies active deglycosylated and glycosidic chain metabolites of Platycodin D targeting PTPN2/HIF1A in acute lung injury

Biology Direct
Background Platycodin D (PD) is a typical triterpenoid saponin with low oral bioavailability. Despite its potent anti-ALI effects, its active metabolites and underlying mechanisms remain unclear, thereby significantly impeding its further development ...
Yuanhan Zhong, Yu Peng, Shouwen Zhang, Liyun Wen, Guangpeng Liu, Bingbing Xu, Yonghong Liang, Huiliang Huang, Junwei He, Yong Feng, Jinxiang Zeng, Jian Liang   +11 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Prevalence of depressive symptoms among Hispanic/Latino ethnic subgroups during the COVID-19 pandemic

Scientific Reports
Hispanic/Latino populations experienced disproportionate exposure to depression risk factors during the COVID-19 pandemic. While aggregated data confirm the risks of depressive symptoms among Hispanic/Latino individuals, little research uses ...
Maryam Elhabashy, Jolyna Chiangong, Kevin Villalobos, Francisco A. Montiel Ishino, David Adzrago, Faustine Williams   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

History

, 2001
Title from title screen.; "Last updated: March 20, 2001."; Harvested from the web on 9/3/02In 1985, the U.S. Department of Health and Human Services issued the Secretary's Task Force Report on Black and Minority Health.
Ohio Commission on Minority Health.
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Introduction to Special Issue “Marginality on the Margins of Europe – The Impact of COVID-19 on Roma Communities in Non-EU Countries in Eastern Europe”

Journal on Ethnopolitics and Minority Issues in Europe, 2022
Andreea Cârstocea, Craig Willis
doaj   +1 more source

Toward an understanding of sexual minority women’s social stressors and health in post-communist countries in Europe: a scoping review

BMC Public Health
Background While significant evidence demonstrates disproportionate burden of poor health among sexual minority men and transgender women, there is a dearth of research on the health of sexual minority women (SMW). We conducted a review to examine social
Lauren Bochicchio, Tonda L. Hughes, Zamfira Parincu, Elizabeth Chadbourne, Corina Lelutiu-Weinberger   +4 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source