Results 61 to 70 of about 29,267 (217)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Molecular characterization, sequence analysis and tissue expression of a porcine gene – MOSPD2

open access: yesBiotechnology & Biotechnological Equipment, 2017
The full-length cDNA sequence of a porcine gene, MOSPD2, was amplified using the rapid amplification of cDNA ends method based on a pig expressed sequence tag sequence which was highly homologous to the coding sequence of the human MOSPD2 gene.
Yang Jie   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Innovation and implementation determinants of HIV testing and linkage-to-care in the U.S.: a systematic review

open access: yesImplementation Science Communications
Objective To identify innovation and implementation determinants of HIV testing, diagnosis, and linkage-to-care in the U.S. Data sources and study setting Between November 2020 and January 2022, a broad search strategy was employed in three literature ...
Alithia Zamantakis   +11 more
doaj   +1 more source

Tournament minors

open access: yesJournal of Combinatorial Theory, Series B, 2015
We say a digraph $G$ is a {\em minor} of a digraph $H$ if $G$ can be obtained from a subdigraph of $H$ by repeatedly contracting a strongly-connected subdigraph to a vertex. Here, we show the class of all tournaments is a well-quasi-order under minor containment.
Kim, Ilhee, Seymour, Paul
openaire   +3 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Discrimination is associated with depression, anxiety, and loneliness symptoms among Asian and Pacific Islander adults during COVID-19 Pandemic

open access: yesScientific Reports
In the United States, Asian and Pacific Islander (A/PI) communities have faced significant discrimination and stigma during the COVID-19 pandemic. We assessed the association between discrimination and depression, anxiety, and loneliness symptoms among ...
Cameron K. Ormiston   +3 more
doaj   +1 more source

Size Versus Intensity of Majority and Minority Consensus to a Persuasive Message: From the Source of Influence to Its Recipients

open access: yesInternational Review of Social Psychology, 2019
This study examines the effects of the evaluation of the majority or minority consensus attributed to a message on the influence the latter can exert, in a between subjects factorial design 2 (consensus status: 'majority' vs 'minority') × 3 (orientation ...
Stamos Papastamou, Gerasimos Prodromitis
doaj   +1 more source

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