Results 51 to 60 of about 1,725 (213)

Religious Diversity and Promotion of Minority Rights, Do They Really Go Hand in Hand?

Religions
One might expect the promotion of religious minority rights to be linked to the growth of religious diversity. However, the data in the Atlas of Religious and Belief Minority Rights, on which this article is based, does not support this expectation ...
Silvio Ferrari
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

If Yes, Why Not? Minority Language Use and Accommodation of Minority Language Rights in Slovakia

Acta Universitatis Sapientiae: European and Regional Studies, 2015
This article gives an overview of the actual situation of language rights in Slovakia, focusing mainly on the minority language usage. The status of minority languages in Slovakia is still a politicized question and a series of conflicts arose especially
Vass Ágnes
doaj   +1 more source

Comment: The Normative Framework of the African Human Rights Regime on the Rights of Minorities

Mizan Law Review, 2015
Minority issues in Africa have surfaced in various dimensions affecting the socio-political landscape of the continent. The protection of minorities is without doubt crucial to securing sustainable peace, economic development as well as protection and ...
B Dessalegn
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Individual and Group Rights of Liberal Multiculturalism

Migracijske i etničke teme, 2010
The paper discusses the implementation of minority members’ protection through political and civil rights. In the debates on minority members’ rights, the issue is whether the very individual rights of traditional liberalism are sufficient for minority ...
Vesna Stanković Pejnović
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Hungarian-Slovak “Cold War” and the Question Of “Hungarians Abroad” in Hungary-Slovakia Relations [PDF]

Romanian Journal of European Affairs, 2009
The question of EU relations with countries of Central and Eastern Europe (CEE) has been widely researched and debated both in political circles and the academia, especially in the light of the EU accession.
Galina Nelaeva
doaj