Results 71 to 80 of about 93,366 (309)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Eritrea: towards unity in diversity
, 1997 Discusses the drawing up of a constitution which will aim to ensure a variety of rights. However, the question remains, how far will these rights be guaranteed in practice?
Pool, David, Pool, D.
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Globalization and “Minority” Cultures [PDF]
, 2014 Globalization and “Minority” Cultures: The Role of “Minor” Cultural Groups in Shaping Our Global Future is a collective work which brings to the forefront of global studies new perspectives on the relationship between globalization and the experiences of
core +2 more sources
Individual and Group Rights of Liberal Multiculturalism
Migracijske i etničke teme, 2010 The paper discusses the implementation of minority members’ protection through political and civil rights. In the debates on minority members’ rights, the issue is whether the very individual rights of traditional liberalism are sufficient for minority ...
Vesna Stanković Pejnović
doaj
Hungarian-Slovak “Cold War” and the Question Of “Hungarians Abroad” in Hungary-Slovakia Relations [PDF]
Romanian Journal of European Affairs, 2009 The question of EU relations with countries of Central and Eastern Europe (CEE) has been widely researched and debated both in political circles and the academia, especially in the light of the EU accession.
Galina Nelaeva
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Minority Veto Rights in Kosovo’s Democracy
Age of Human Rights Journal, 2019 The political system of Kosovo belongs to the power sharing democracies. Indeed, it has all the characteristics of Consociational Democracy. In addition to that, minority veto rights are absolute and go above the aims of this type of democracy. As it is
Behar Selimi
doaj +2 more sources
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source