miR-132-3p priming enhances the effects of mesenchymal stromal cell-derived exosomes on ameliorating brain ischemic injury [PDF]
Stem Cell Research & Therapy, 2020 Backgrounds/aims Mesenchymal stromal cell-derived exosomes (MSC-EXs) could exert protective effects on recipient cells by transferring the contained microRNAs (miRs), and miR-132-3p is one of angiogenic miRs.
Qunwen Pan +11 more
doaj +10 more sources
miR-132-3p and KLF7 as novel regulators of aortic stiffening-associated EndMT in type 2 diabetes mellitus [PDF]
Diabetology & Metabolic Syndrome, 2023 Background The prevalence of diabetes mellitus has risen considerably and currently affects more than 422 million people worldwide. Cardiovascular diseases including myocardial infarction and heart failure represent the major cause of death in type 2 ...
Melanie S. Hulshoff +10 more
doaj +11 more sources
Lung cancer-derived exosomal miR-132-3p contributed to interstitial lung disease development [PDF]
World Journal of Surgical Oncology, 2023 Purpose Interstitial lung diseases (ILDs) have high morbidity and mortality and poor prognosis. The significance of microRNAs (miRNAs) was highlighted in ILDs development.
Sufang Fang +5 more
doaj +6 more sources
Exosomal miR-132-3p from mesenchymal stromal cells improves synaptic dysfunction and cognitive decline in vascular dementia [PDF]
Stem Cell Research & Therapy, 2022 Background/aims Vascular dementia (VD) results in cognition and memory deficit. Exosomes and their carried microRNAs (miRs) contribute to the neuroprotective effects of mesenchymal stromal cells, and miR-132-3p plays a key role in neuron plasticity. Here,
Xiaotang Ma +7 more
doaj +7 more sources
MTFR2 promotes endometrial carcinoma cell proliferation and growth via the miR-132-3p/PI3K/Akt signaling pathway [PDF]
Frontiers in MedicineObjectiveUnderstanding the mechanisms underlying endometrial cancer progression is crucial for the development of effective targeted therapies. In this study, we investigated the role of MTFR2 in endometrial cancer cell.MethodsThe expression of MTFR2 in ...
Zhijun Niu +7 more
doaj +7 more sources
miRNA profiling during antigen-dependent T cell activation: A role for miR-132-3p. [PDF]
Sci Rep, 2017 microRNAs (miRNAs) are tightly regulated during T lymphocyte activation to enable the establishment of precise immune responses. Here, we analyzed the changes of the miRNA profiles of T cells in response to activation by cognate interaction with ...
Gutiérrez-Vázquez C +8 more
europepmc +13 more sources
miR-132-3p is a positive regulator of alpha-cell mass and is downregulated in obese hyperglycemic mice [PDF]
Molecular Metabolism, 2019 Objective: Diabetes is a complex disease implicating several organs and cell types. Within the islets, dysregulation occurs in both alpha- and beta-cells, leading to defects of insulin secretion and increased glucagon secretion.
Rodolphe Dusaulcy +5 more
doaj +5 more sources
miR-132-3p downregulates in CD4 T cells and is associated with disease manifestations in patients with lupus [PDF]
Journal of International Medical ResearchObjective This study aimed to evaluate the expression status of miR-132-3p in CD4 + T cells in patients with systemic lupus erythematosus (SLE) and explore its potential role in SLE development.
Haihong Qin +5 more
doaj +3 more sources
MiR-132-3p Modulates MEKK3-Dependent NF-κB and p38/JNK Signaling Pathways to Alleviate Spinal Cord Ischemia-Reperfusion Injury by Hindering M1 Polarization of Macrophages [PDF]
Frontiers in Cell and Developmental Biology, 2021 Spinal cord ischemia-reperfusion (SCIR) injury is a serious complication of open surgical and endovascular aortic procedures. MicroRNA-132-3p (miR-132-3p) has been reported to be involved in the progression of various diseases, but its role in SCIR ...
Hua Fang +17 more
doaj +4 more sources
Integrated analysis of miRNAs and DNA methylation identifies miR‐132‐3p as a tumor suppressor in lung adenocarcinoma [PDF]
Thoracic Cancer, 2020 Background Aberrant miRNA expression and DNA methylation are two major epigenetic events in lung adenocarcinoma (LUAD). We conducted a combined analysis of the molecular changes in LUAD.
Yun Su, Amol Shetty, Feng Jiang
doaj +3 more sources