Results 91 to 100 of about 54,811 (219)

Blockade of miR-140-3p prevents functional deterioration in afterload-enhanced engineered heart tissue

Scientific Reports, 2019
Afterload enhancement (AE) of rat engineered heart tissue (EHT) in vitro leads to a multitude of changes that in vivo are referred to as pathological cardiac hypertrophy: e.g., cardiomyocyte hypertrophy, contractile dysfunction, reactivation of fetal ...
Tessa R. Werner, Ann-Cathrin Kunze, Justus Stenzig, Thomas Eschenhagen, Marc N. Hirt   +4 more
doaj   +1 more source

Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury-EpiBioS4Rx Project 1 study. [PDF]

OBJECTIVE: To test a hypothesis that acutely regulated plasma microRNAs (miRNAs) can serve as prognostic biomarkers for the development of post-traumatic epilepsy (PTE).
Ali, Idrish, Andrade, Pedro, Brady, Rhys, Braine, Emma, Casillas-Espinosa, Pablo, Gröhn, Olli, Gupta, Shalini, Harris, Neil, Heiskanen, Mette, Hudson, Matt, Immonen, Riikka, Jones, Nigel, Manninen, Eppu, Ndode-Ekane, Xavier, OBrien, Terence, Pitkänen, Asla, Puhakka, Noora, Santana-Gomez, Cesar, Shultz, Sandy, Silva, Juliana, Smith, Gregory, Staba, Richard, Wright, David, Yamakawa, Glen   +23 more
core   +1 more source

Regulation of microRNA during cardiomyocyte maturation in sheep. [PDF]

, 2015
BACKGROUND: There is a limited capacity to repair damage in the mammalian heart after birth, which is primarily due to the inability of cardiomyocytes to proliferate after birth.
Botting, Kimberley J, Brooks, Doug A, McMillen, I Caroline, Morrison, Janna L, Porrello, Enzo R, Tellam, Ross L, Zhang, Song   +6 more
core   +2 more sources

Electrochemical Nitrate Reduction Reaction to Ammonia at Industrial‐Level Current Densities

Advanced Science, EarlyView.
This review starts from the mechanism and theoretical basis of electrochemical nitrate reduction reaction (NO3−RR), and systematically summarizes and discusses the design strategies of industrial‐level current density catalysts. In addition, the progress of industrial‐level NO3−RR‐based electrolyzers, including flow reactor and membrane electrode ...
Zhijie Cui, Honghai Wang, Chunli Li, Wenchao Peng, Jiapeng Liu   +4 more
wiley   +1 more source

Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones [PDF]

, 2016
Background Better insights into the molecular changes involved in virus-associated and -independent head and neck cancer may advance our knowledge of HNC carcinogenesis and identify critical disease biomarkers.
Grega, Marek, Klozar, Jan, Prochazka, Bohumir, Sabol, Ivan, Salakova, Martina, Smahelova, Jana, Tachezy, Ruth, Turek, Lubomir, Vojtechova, Zuzana, Zavadil, Jiri   +9 more
core   +9 more sources

THE ROLE OF MICRORNAS (MIRNAs) IN THE REGULATION OF TAU PATHOLOGY [PDF]

, 2020
Tauopathies are a class of sporadic neurodegenerative disorders including Alzheimer’s disease (AD), Pick’s disease, Corticobasal degeneration and Progressive supranuclear palsy, characterized by hyperphosphorylation and aggregation of the microtubule ...
LAURETTI, ELISABETTA
core   +1 more source

Tailored Design of Iridium Single Atoms on Mn–Ni‐Phytate with Robust Bifunctionality for Enhanced Anion Exchange Membrane Water Electrolysis

Advanced Energy Materials, EarlyView.
This work presents a manganese‐doped nickel hydroxide scaffold that anchors iridium as isolated single atoms (SAs) using a phytate ligand. The hierarchical nanoarray catalyst efficiently drives simultaneous hydrogen and oxygen evolution in alkaline media, enabling industrial‐level current densities and long‐term stability in an anion‐exchange‐membrane ...
Quynh Phuong Ngo, Sae Yane Paek, Jun Young Lee, Ho Ngoc Nam, Quan Manh Phung, Thanh Hai Nguyen, Jin Young Seo, Yusuke Yamauchi, Le Hoang Sinh, Yun Jung Lee, Jong Min Kim, Jongbeom Na   +11 more
wiley   +1 more source

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria [PDF]

, 2016
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory ...
A Bhoumik, A Bhoumik, A Montecalvo, A Subtil, AK Bei, AT Argaw, C Barres, C Lamaze, C Lawrie, CJ Hemmer, CJ Murray, D Cifuentes, D Nantakomol, DM Patrick, DM Pegtel, DP Bartel, E Lau, E Macia, E Pongponratn, F Tabet, G Lv, G Meister, G Meister, GD Turner, GL Genrich, H Brown, H Valadi, J Baum, J Lu, J Skog, JD Arroyo, KC Vickers, KE Jackson, KM Schweitzer, KN Couper, L Song, LC Dore, LH Miller, M Bastiani, M Dreux, M Klemba, M Raab, M Trajkovski, M Zhan, MI Lin, MP Alves, MP Perron, N Regev-Rudzki, P Landry, P Pino, P Yin, PM Bauer, PY Mantel, R Jambou, R Martinelli, RM O'Connell, S Cheloufi, S Laurance, SY Chen, T Lopotova, UA Orom, V Boonpucknavig, V Combes, Y Lee, Y Zhang   +64 more
core   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Circulating MicroRNAs as potential biomarkers for cerebral collateral circulation in symptomatic carotid stenosis

Frontiers in Physiology
BackgroundCerebral collateral circulation (CCC) considerably improves the prognosis of patients with symptomatic carotid stenosis (SCS). This study evaluated the diagnostic value of plasma microRNAs (miRNAs) in determining CCC status in patients with SCS.
Wenwen Liang, Bingcang Huang, Qin Shi, Xuelian Yang, Hanwen Zhang, Wei Chen   +5 more
doaj   +1 more source