Results 101 to 110 of about 21,775 (165)

The synergistic impact of sleep duration and obesity on metabolic syndrome risk: exploring the role of microRNAs [PDF]

BioImpacts
Introduction: Given the well-established association between metabolic syndrome (MetS) and obesity, this study elucidates the influences of sleep duration and weight on MetS risk and explores the potential role of miRNAs as underlying mechanisms. Methods:
Atefeh Ansarin, Dariush Shanehbandi, Habib Zarredar, Alireza Ostadrahimi, Neda Gilani, Khalil Ansarin   +5 more
doaj   +1 more source

A specific microRNA profile as predictive biomarker for systemic treatment in patients with metastatic colorectal cancer

Cancer Medicine, 2020
Background Palliative systemic therapy is currently standard of care for patients with extensive metastatic colorectal cancer (mCRC). A biomarker predicting chemotherapy benefit which prevents toxicity from ineffective treatment is urgently needed ...
Dennis Poel, Elske C. Gootjes, Lotte Bakkerus, Wim Trypsteen, Henk Dekker, Hans J. van derVliet, Nicole C. T. vanGrieken, Cornelis Verhoef, Tineke E. Buffart, Henk M. W. Verheul   +9 more
doaj   +1 more source

Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression

, 2021
Qing-Ke Li, Yan-Kun Liu, Jing-Wu Li, Yuanting Liu, Yufeng Li, Binghui Li   +5 more
openalex   +2 more sources

Understanding the mechanism of cardiac gene remodelling via PPAR-α signalling in cardiac hypertrophy [PDF]

, 2022
identified and unveiled the functional relevance of differentially expressed miRNAs in ISO-treated PPAR α-/- mice. As of now, limited literature was available about miRNA abundance and their altered expression in cardiac hypertrophy models in the ...
KUMARI, RITU
core  

Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease

Clinical and Translational Medicine
Background Crohn's disease (CD) is a chronic inflammatory disease in the intestinal tract. Mesenteric fat wrapping and thickening, or creeping fat (CrF), is a typical characteristic of CD and it involves lymphangiogenesis and altered lymphatic function ...
Weigang Shu, Yongheng Wang, Mengfan Chen, Xiaoli Zhu, Fangtao Wang, Chunqiu Chen, Peng Du, Alexandra Bartolomucci, Xin Su, Xiaolei Wang   +9 more
doaj   +1 more source

Mesenchymal Stem Cell-Extracellular Vesicle Therapy for Stroke: Scalable Production and Imaging Biomarker Studies [PDF]

, 2023
A major clinical hurdle to translate MSC-derived extracellular vesicles (EVs) is the lack of a method to scale-up the production of EVs with customized therapeutic properties.
Bang, Oh Young, Cha, Jae Min, Chopp, Michael, Kim, Dong Hee, Kim, Eun Hee, Oh, Mi Jeong, Shin, Eun Kyoung, Son, Jeong Pyo, Sung, Ji Hee   +8 more
core  

Artificial mesenchymal stem cell extracellular vesicles enhanced ischemic stroke treatment through targeted remodeling brain microvascular endothelial cells

Acta Pharmaceutica Sinica B
Ischemic stroke is the leading cause of disability and mortality worldwide. The blood‒brain barrier (BBB) is the first line of defense after ischemic stroke.
Shengnan Li, Wei Lv, Jiangna Xu, Jiaqing Yin, Yuqin Chen, Linfeng Liu, Xiang Cao, Wenjing Li, Zhen Li, Hua Chen, Hongliang Xin   +10 more
doaj   +1 more source

Temporal deregulation of genes and microRNAs in neurons during prion-induced neurodegeneration [PDF]

, 2010
Prion diseases are fatal and incurable neurodegenerative diseases that share many pathological similarities to other neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease. One of the earliest pathological signs commonly detected in all of
Majer, Anna
core   +2 more sources

Circulating microRNAs as Biomarkers of Various Forms of Epilepsy

Medical Sciences
Background: Epilepsy is a group of disorders characterized by a cluster of clinical and EEG signs leading to the formation of abnormal synchronous excitation of neurons in the brain.
Elena E. Timechko, Kristina D. Lysova, Alexey M. Yakimov, Anastasia I. Paramonova, Anastasia A. Vasilieva, Elena A. Kantimirova, Anna A. Usoltseva, Albina V. Yakunina, Irirna G. Areshkina, Diana V. Dmitrenko   +9 more
doaj   +1 more source

Genomic gain/methylation modification/hsa-miR-132-3p increases RRS1 overexpression in liver hepatocellular carcinoma. [PDF]

Cancer Sci, 2023
Zhang X, Cong P, Tian L, Zheng Y, Zhang H, Liu Q, Wu T, Zhang Q, Wu H, Huang X, Xiong L.   +10 more
europepmc   +1 more source