Results 121 to 130 of about 54,811 (219)

Understanding the mechanism of cardiac gene remodelling via PPAR-α signalling in cardiac hypertrophy [PDF]

, 2022
identified and unveiled the functional relevance of differentially expressed miRNAs in ISO-treated PPAR α-/- mice. As of now, limited literature was available about miRNA abundance and their altered expression in cardiac hypertrophy models in the ...
KUMARI, RITU
core  

Nanoformulated Diacerein Alleviates Hyperlipidemia via Gut Microbiota Modulation In Vivo

Nano Select, EarlyView.
A nanoformulation of diacerein (Nano‐DIA) was fabricated with carboxymethyl cellulose, achieving enhanced solubility and rapid dissolution for alternative anti‐hyperlipidemia therapeutics. Mechanistic studies revealed its in vivo lipid‐lowering efficacy is through metabolite‐mediated and microbiota‐dependent manner, highlighting its dual action on host
Zheng Peng, Yi Yu, Mingyi Chen, Weibin Wu, Chunyan Zhu, Caisheng Wu, Weihua Li, Zehua Liu, Qiang Xie   +8 more
wiley   +1 more source

Spinel Aluminate‐Based Heterojunctions as Photocatalyst: A Review

ChemistryOpen, EarlyView.
Spinel aluminates (MAl2O4; M = Zn, Mg, Ca, Sr) serve as robust platforms for designing heterojunction photocatalysts. Their stable lattices, tunable band structures, and efficient charge transport enable improved light‐driven carrier separation, significantly enhancing pollutant degradation efficiency in advanced photocatalytic systems.
Ancy Kurian, Sumathi Shanmugam
wiley   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Mesenchymal Stem Cell-Extracellular Vesicle Therapy for Stroke: Scalable Production and Imaging Biomarker Studies [PDF]

, 2023
A major clinical hurdle to translate MSC-derived extracellular vesicles (EVs) is the lack of a method to scale-up the production of EVs with customized therapeutic properties.
Bang, Oh Young, Cha, Jae Min, Chopp, Michael, Kim, Dong Hee, Kim, Eun Hee, Oh, Mi Jeong, Shin, Eun Kyoung, Son, Jeong Pyo, Sung, Ji Hee   +8 more
core  

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Artificial mesenchymal stem cell extracellular vesicles enhanced ischemic stroke treatment through targeted remodeling brain microvascular endothelial cells

Acta Pharmaceutica Sinica B
Ischemic stroke is the leading cause of disability and mortality worldwide. The blood‒brain barrier (BBB) is the first line of defense after ischemic stroke.
Shengnan Li, Wei Lv, Jiangna Xu, Jiaqing Yin, Yuqin Chen, Linfeng Liu, Xiang Cao, Wenjing Li, Zhen Li, Hua Chen, Hongliang Xin   +10 more
doaj   +1 more source

Temporal deregulation of genes and microRNAs in neurons during prion-induced neurodegeneration [PDF]

, 2010
Prion diseases are fatal and incurable neurodegenerative diseases that share many pathological similarities to other neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease. One of the earliest pathological signs commonly detected in all of
Majer, Anna
core   +2 more sources

The Diagnostic Value of Blood Mir-132-3p Level in Patients with Alzheimer's Disease

Abstract Objective: To investigate the relationship between miR-132-3p level in circulating blood and the degree of cognitive impairment and hippocampal atrophy in Alzheimer's disease (AD) patients, as well as its diagnostic value. Methods: The expression level of miR-132-3p in brain tissue between early and late AD patients and between AD ...
Hao Zhang, Xiaofeng Fu, Xiaoyi Ren, Yuying Qi, Xiaowen Song, Ning Zhu, Mengyu Yang, Yingying Dong, Min Li, Yan Tian, Xuezhen Wang   +10 more
openaire   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source