Results 131 to 140 of about 54,811 (219)

Circulating microRNAs as Biomarkers of Various Forms of Epilepsy

Medical Sciences
Background: Epilepsy is a group of disorders characterized by a cluster of clinical and EEG signs leading to the formation of abnormal synchronous excitation of neurons in the brain.
Elena E. Timechko, Kristina D. Lysova, Alexey M. Yakimov, Anastasia I. Paramonova, Anastasia A. Vasilieva, Elena A. Kantimirova, Anna A. Usoltseva, Albina V. Yakunina, Irirna G. Areshkina, Diana V. Dmitrenko   +9 more
doaj   +1 more source

Navigating a landscape of contrasting hunting regimes and habitats: red deer responses to risk and resources

Wildlife Biology, EarlyView.
Habitat selection of ungulates is influenced by various factors, with human interactions playing a significant role. Human disturbances through hunting strongly affect ungulate behaviour, often forcing them to modify their habitat choices by avoiding areas where the risk from humans outweighs other habitat benefits. Gaining insights into these dynamics
Juliana Eggers, Michael Maroschek, Rupert Seidl, Sina Greiner, Matthias Loretto, Sebastian Seibold, Rudolf Reiner   +6 more
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Homo luzonensis and the role of homoplasy in the morphology of hominin insular species

Cladistics, EarlyView.
Abstract Homo luzonensis lived during the upper Pleistocene in the northern Philippines, east of the Wallace line. The few specimens attributed to this species show a mosaic of plesiomorphies for the genus Homo and apomorphies found in upper Pleistocene Homo species.
Pierre Gousset, Jérémie Bardin, Isabelle Rouget, Armand S. Mijares, Florent Détroit   +4 more
wiley   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

M2 macrophage-derived exosomes promote angiogenesis and improve cardiac function after myocardial infarction

Biology Direct
Background Myocardial infarction (MI) is a major cause of mortality and morbidity worldwide. The intercellular communication in post-infarction angiogenesis remains unclear.
Hongzhou Guo, Zeya Li, Bin Xiao, Rongchong Huang   +3 more
doaj   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Inference via the Skewness‐Kurtosis Set

International Statistical Review, EarlyView.
Summary Kurtosis minus squared skewness is bounded from below by 1, but for unimodal distributions, this parameter is bounded by 189/125. In some applications, it is natural to compare distributions by comparing their kurtosis‐minus‐squared‐skewness parameters. The asymptotic behavior of the empirical version of this parameter is studied here for i.i.d.
Chris A. J. Klaassen, Bert van Es
wiley   +1 more source