Results 151 to 160 of about 21,775 (165)

The Regulation of Exosome-Mediated miR-132-3p/miR-132-3p-UUU on Radiation-Induced Esophageal Injury

Radiation Research, 2023
Radiation-induced esophageal injury (RIEI) is a major dose-limiting complication of radiotherapy, mainly acute esophagitis. However, understanding of radiation injury and repair mechanisms in esophageal epithelial cells remains limited. MiR-132-3p and its uridylated isoform (miR-132-3p-UUU) are upregulated in radiation esophageal injury, yet their role
Muzi, Liu, Zhiqiang, Sun, Yiting, Tang, Shuyu, Zhang, Judong, Luo   +4 more
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The outstanding role of miR-132-3p in carcinogenesis of solid tumors

Human Cell, 2021
MicroRNAs are a group of short non-coding RNAs (miRNAs), which are epigenetically involved in gene expression and other cellular biological processes and can be considered as potential biomarkers for cancer detection and support for treatment management.
Milad Rafat, Mahta Moraghebi, Masoumeh Afsa, Kianoosh Malekzadeh   +3 more
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MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis

Cellular Signalling, 2023
The pathogenesis of renal ischemic diseases remains unclear. In this study, we demonstrate the induction of microRNA-132-3p (miR-132-3p) in ischemic acute kidney injury (AKI) and cultured renal tubular cells under oxidative stress. miR-132-3p mimic increased apoptosis in renal tubular cells and enhanced ischemic AKI in mice, whereas miR-132-3p ...
Chenglong, Li, Shangting, Han, Jiefu, Zhu, Fan, Cheng   +3 more
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Circulating miR-146a-5p and miR-132–3p as potential diagnostic biomarkers in epilepsy

Epilepsy Research, 2023
MiRNAs are important gene-regulating agents in epilepsy development, according to new research. The purpose of this study is to investigate the relationship between serum expression of miR-146a-5p and miR-132-3p and epilepsy in Egyptian patients as potential diagnostic and therapeutic biomarkers.MiR-146a-5p and miR-132-3p were measured in the serum of ...
Azhar Mohamed, Nomair, Jaidaa Farouk, Mekky, Shaymaa Ali, El-Hamshary, Hanan Mohamed, Nomeir   +3 more
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Arid2-IR downregulates miR-132-3p through methylation to promote LPS-induced ALI in pneumonia

Inhalation Toxicology, 2022
Arid2-IR is a long non-coding RNA (lncRNA) that promotes renal injury, while its role in lipopolysaccharides (LPS)-induced acute lung injury (ALI) is unknown. Our preliminary sequencing analysis revealed an inverse correlation of Arid2-IR and miR-132-3p, which is known to suppress LPS-induced ALI.
Yuanshui, Liu, Chuanyu, Bao, Gongping, Deng, Yanhong, Ouyang   +3 more
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LINC00858 facilitates formation of hepatic metastases from colorectal cancer via regulating the miR-132-3p/IGF2BP1 axis

Biological Chemistry, 2023
Abstract Hepatic metastasis is a major cause of colorectal cancer (CRC)-related deaths. Presently, the role of long non-coding RNAs (lncRNAs) in hepatic metastases from CRC is elusive. We dissected possible interplay between LINC00858/miR-132-3p/IGF2BP1 via bioinformatics approaches. Subsequently we analyzed mRNA expression of LINC00858,
Peng, Sun, Yusong, Luan, Xuhao, Cai, Qi, Liu, Peide, Ren, Panxin, Peng, Yonggang, Yu, Bolun, Song, Yangyang, Wang, Huijing, Chang, Haoyue, Ma, Yinggang, Chen   +11 more
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MiR-132-3p serves as a tumor suppressor in mantle cell lymphoma via directly targeting SOX11

Naunyn-Schmiedeberg's Archives of Pharmacology, 2020
Mantle cell lymphoma (MCL) is an uncommon type of non-Hodgkin's lymphoma (NHL), comprising about 6% of NHL cases. SOX11 is a member of the group C of Sry-related high-mobility group (HMG) box (Sox) transcription factors, which is ubiquitously expressed in approximate 90% MCL cases.
Baoyu, Wu, Jingyu, Li, Han, Wang, Qian, Wu, Hui, Liu   +4 more
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Selenomethionine-Modified Polyethylenimine-Based Nanoparticles Loaded with miR-132-3p Inhibitor-Biofunctionalized Titanium Implants for Improved Osteointegration

ACS Biomaterials Science & Engineering, 2021
Titanium and its alloys have been widely used as bone implants, but for reduced treatment span, improvements are urgently needed to achieve faster and better osteointegration. In this study, we found that miR-132-3p inhibited bone-marrow-derived stem cell (BMSC) osteogenic differentiation via targeting BMP2, and that inhibiting miR-132-3p could ...
Yiming Li, Guanhui Chen, Yi He, Chen Yi, Xiliu Zhang, Binghui Zeng, Ziqing Huang, Feilong Deng, Dongsheng Yu   +8 more
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MiR‐132‐3p regulates ADAMTS‐5 expression and promotes chondrogenic differentiation of rat mesenchymal stem cells

Journal of Cellular Biochemistry, 2017
AbstractPrevious study showed that miRNA aberrant expression is involved in chondrogenic differentiation. In this study, we aimed to investigate the effects of miR‐132‐3p on chondrogenic differentiation and the underlying mechanisms. First, quantitative PCR were performed to determine the level of MiR‐132‐3p.
Xiaozhong Zhou, Dixin Luo, Hongtao Sun, Yong Qi, Wangyang Xu, Xunjie Jin, Chao Li, Zhousheng Lin, Guitao Li   +8 more
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Downregulation of GSK3B by miR-132-3p Enhances Etoposide-Induced Breast Cancer Cell Apoptosis.

Annals of clinical and laboratory science, 2021
MicroRNAs (miRNAs) have been confirmed to play an essential role in modulating cancer cell proliferation, metastasis, and sensitivity to chemotherapy. However, the correlation between miR-132-3p expression and etoposide (VP16) induced apoptosis in human breast cancer cells remains poorly understood.Six datasets, including three gene expression profile ...
Chengshan, Xu, Zhongli, Du, Simei, Ren, Yaya, Pian   +3 more
openaire   +1 more source