Mechanism of miR-132-3p Promoting Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson's Disease. [PDF]
eNeuro, 2022 Visual Abstract The major pathology in Parkinson’s disease (PD) is neuron injury induced by degeneration of dopaminergic neurons and the activation of microglial cells. The objective of this study is to determine the effect and mechanism of miR-132-3p in
Gong X, Huang M, Chen L.
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MBNL1-AS1 Promotes Hypoxia-Induced Myocardial Infarction via the miR-132-3p/RAB14/CAMTA1 Axis. [PDF]
Oxid Med Cell Longev, 2023 Background Mounting evidence have indicated that long noncoding RNA (lncRNA) muscleblind like splicing regulator 1 antisense RNA 1 (MBNL1-AS1) play a crucial regulatory role in cardiovascular disease, myocardial infarction (MI) included. In this research,
Li Y +6 more
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LncRNA XIST knockdown alleviates LPS-induced acute lung injury by inactivation of XIST/miR-132-3p/MAPK14 pathway : XIST promotes ALI via miR-132-3p/MAPK14 axis. [PDF]
Mol Cell Biochem, 2021 Acute lung injury (ALI) is a fatal inflammatory response syndrome. LncRNA XIST (XIST) is a lung cancer-related gene and participates in pneumonia. However, whether XIST participates in lipopolysaccharides (LPS)-induced ALI remains unclear.
Li C +6 more
europepmc +5 more sources
Targeting kinesin family member 21B by miR-132-3p represses cell proliferation, migration and invasion in gastric cancer. [PDF]
Bioengineered, 2022 Recently, kinesin family member 21B (KIF21B) has been reported to be an oncogene in non-small cell lung cancer and hepatocellular carcinoma. However, the functional role of KIF21B and related molecular mechanisms in gastric cancer (GC) remain largely ...
Liu B, Qiang L, Guan B, Ji Z.
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Autoimmunity, 2021 Exosomes isolated from mesenchymal stem cells (MSC) had shown beneficial effect on acute lung injury (ALI). However, the effective components in MSC-derived exosomes need further investigation.
Jian-Hua Liu +4 more
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miR-132-3p regulates antibody-mediated complement-dependent cytotoxicity in colon cancer cells by directly targeting CD55. [PDF]
Clin Exp Immunol, 2023 The overexpression of membrane-bound complement regulatory proteins (mCRPs) on tumour cells helps them survive complement attacks by suppressing antibody-mediated complement-dependent cytotoxicity (CDC).
Fan Y +5 more
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miR-132–3p is down-regulated in plasma and CD171+ extracellular vesicles isolated from patients with mild Alzheimer’s disease [PDF]
Mechanisms of Ageing and DevelopmentAlzheimer’s disease (AD), the most prevalent neurodegenerative disorder in aging populations, demands minimally invasive biomarkers for early diagnosis and monitoring. Circulating microRNAs (miRNAs) show promise as such biomarkers.
Matilde Sbriscia +17 more
semanticscholar +8 more sources
miRNA profiling during antigen-dependent T cell activation: A role for miR-132-3p. [PDF]
Sci Rep, 2017 microRNAs (miRNAs) are tightly regulated during T lymphocyte activation to enable the establishment of precise immune responses. Here, we analyzed the changes of the miRNA profiles of T cells in response to activation by cognate interaction with ...
Gutiérrez-Vázquez C +8 more
europepmc +10 more sources
Long Non-Coding RNA SNHG16 Activates USP22 Expression to Promote Colorectal Cancer Progression by Sponging miR-132-3p. [PDF]
Onco Targets Ther, 2020 Background Colorectal cancer (CRC) is the most common cause of cancer-related mortality in the world. Long non-coding RNAs (lncRNAs) are involved in the development of many cancers.
He X, Ma J, Zhang M, Cui J, Yang H.
europepmc +5 more sources
miR-132-3p is a positive regulator of alpha-cell mass and is downregulated in obese hyperglycemic mice [PDF]
Molecular Metabolism, 2019 Objective: Diabetes is a complex disease implicating several organs and cell types. Within the islets, dysregulation occurs in both alpha- and beta-cells, leading to defects of insulin secretion and increased glucagon secretion.
Rodolphe Dusaulcy +5 more
doaj +4 more sources