Results 41 to 50 of about 54,811 (219)

Withdrawn: MiR‐132‐3p promotes neuroinflammation and dopaminergic neurodegeneration by suppressing glutaredoxin expression [PDF]

Journal of Neurochemistry, 2021
This study aimed to investigate the effect of miR-132-3p/GLRX on neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease (PD). In clinical experiments, the levels of miR-132-3p and glutaredoxin (GLRX) in the midbrain tissuesfrom 5 patients with PD were analyzed by qRT-PCR and Western blotting.
openaire   +2 more sources

Gene expression and microrna expression analysis in small arteries of spontaneously hypertensive rats. Evidence for er stress [PDF]

, 2015
Small arteries are known to develop functional and structural alterations in hypertension. However, the mechanisms of this remodeling are not fully understood.We hypothesized that altered gene expression is associated with the development of ...
Arribas, Silvia M., Bakker, Erik N T P, De Vos, Judith, Groma, Gergely, Jongejan, Aldo, Moerland, Perry D., Palao, Teresa, Swärd, Karl, Van Bavel, Ed, Van Weert, Angela   +9 more
core   +14 more sources

Aberrant expression of microRNA-132-3p and microRNA-146a-5p in Parkinson’s disease patients

Open Life Sciences, 2020
Parkinson’s disease (PD) is an age-related neurodegenerative disorder which is assessed based on the motor symptoms. A number of microRNAs (miRNAs) are dysregulated and involved in the pathogenesis or development of PD.
Shu Yu, Qian Jinjun, Wang Chunyan
doaj   +1 more source

miR-132-3p participates in the pathological mechanism of temporomandibular joint osteoarthritis by targeting PTEN

Archives of Oral Biology, 2022
This study aimed to investigate the role of miR-132-3p in the progression of temporomandibular joint osteoarthritis (TMJOA) and its potential pathological mechanism.A TMJOA model was established using six rats via the unilateral anterior crossbite method.
Libo, Zhou, Deping, Chen, Penghui, Liu, Lei, Chen, Yucheng, Su   +4 more
openaire   +2 more sources

Effect of miR-132-3p on epithelial-mesenchymal transition of trophoblast cells by targeting the SIRT1/NF-κB pathway [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of miR-132-3p on epithelial-mesenchymal transition (EMT) of trophoblast cells through targeted regulation of the SIRT1/NF-κB pathway.
GUO Shuhuan, GAO Yali, CHEN Jingge
doaj   +1 more source

Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate muscle atrophy via the miR-132-3p/FoxO3 axis. [PDF]

J Orthop Translat
Muscle atrophy or sarcopenia is the loss of muscle mass and strength and leads to an increased risk of disability and death including osteoporotic fractures. Currently, there are no available clinical biologic agents for the treatment of sarcopenia. Since exosomes have become increasingly attractive as a novel therapeutic approach due to their ability ...
Ma H, Jing Y, Zeng J, Ge J, Sun S, Cui R, Qian C, Qu S, Sheng H.   +8 more
europepmc   +4 more sources

Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa-miR-132-3p/Sox5 signalling pathway. [PDF]

Cell Prolif, 2019
AbstractObjectivesTo reveal the role of circular RNA (circRNA) DOCK1 (circDOCK1) as a potential biomarker and therapeutic target and its competing endogenous RNA mechanism in bladder carcinoma (BC).MethodsThe next‐generation sequencing (NGS) technology was introduced to screen the circRNA expression profiles of BC using microarray.
Liu P, Li X, Guo X, Chen J, Li C, Chen M, Liu L, Zhang X, Zu X.   +8 more
europepmc   +4 more sources

Music-listening regulates human microRNA expression

Epigenetics, 2021
Music-listening and performance have been shown to affect human gene expression. In order to further elucidate the biological basis of the effects of music on the human body, we studied the effects of music-listening on gene regulation by sequencing ...
Preethy Sasidharan Nair, Pirre Raijas, Minna Ahvenainen, Anju K. Philips, Liisa Ukkola-Vuoti, Irma Järvelä   +5 more
doaj   +1 more source

Circulating MicroRNAs as Quantitative Biomarkers for Diagnosis and Prognosis of Uveal Melanoma

Frontiers in Oncology, 2022
For uveal melanoma (UM) patients, it is significant to establish diagnosis and prognosis evaluation systems through imaging techniques. However, imaging examinations are short of quantitative biomarkers and it is difficult to finish early diagnosis of UM.
Wen-Da Zhou, Lei Shao, Li Dong, Rui-Heng Zhang, Yi-Fan Li, He-Yan Li, Hao-Tian Wu, Xu-Han Shi, Wen-Bin Wei   +8 more
doaj   +1 more source

Pathogenetic and diagnostic significance of microRNA deregulation in peripheral T-cell lymphoma not otherwise specified [PDF]

, 2014
Peripheral T-cell lymphomas not otherwise specified (PTCLs/NOS) are rare and aggressive tumours whose molecular pathogenesis and diagnosis are still challenging.
Agostinelli, C., Bacci, E., Barrese, T., Clò, A., Croce, C., Etebari, M., Fuligni, F., Gazzola, A., Gibellini, D., Inghirami, G., Laginestra, M., Mannu, C., Melle, F., Motta, G., Piccaluga, P., Pileri, S., Righi, S., Rossi, M., Sabattini, E., Sacchetti, C., Sapienza, M., Tabanelli, V., TRIPODO, Claudio   +22 more
core   +3 more sources