The Stress-Responding miR-132-3p Shows Evolutionarily Conserved Pathway Interactions. [PDF]
Cell Mol Neurobiol, 2018 MicroRNAs (miRNAs) are small non-coding RNA chains that can each interact with the 3'-untranslated region of multiple target transcripts in various organisms, humans included. MiRNAs tune entire biological pathways, spanning stress reactions, by regulating the stability and/or translation of their targets.
Haviv R, Oz E, Soreq H.
europepmc +4 more sources
Upregulation of miR‑132‑3p in cholangiocarcinoma tissues: A study based on RT‑qPCR, The Cancer Genome Atlas miRNA sequencing, Gene Expression Omnibus microarray data and bioinformatics analyses. [PDF]
Mol Med Rep, 2019 Wu HY +9 more
europepmc +3 more sources
Archives of Oral Biology, 2022 This study aimed to investigate the role of miR-132-3p in the progression of temporomandibular joint osteoarthritis (TMJOA) and its potential pathological mechanism.A TMJOA model was established using six rats via the unilateral anterior crossbite method.
Libo Zhou +4 more
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Increased miR-132-3p expression is associated with chronic neuropathic pain. [PDF]
Exp Neurol, 2016 Alterations in the neuro-immune balance play a major role in the pathophysiology of chronic neuropathic pain. MicroRNAs (miRNA) can regulate both immune and neuronal processes and may function as master switches in chronic pain development and maintenance.
Leinders M +4 more
europepmc +6 more sources
Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear [PDF]
, 2023 Social interactions are critical for mammalian survival and evolution. Dysregulation of social behavior often leads to psychopathologies such as social anxiety disorder, denoted by intense fear and avoidance of social situations.
Bludau, Anna +6 more
core +1 more source
Gene expression and microrna expression analysis in small arteries of spontaneously hypertensive rats. Evidence for er stress [PDF]
, 2015 Small arteries are known to develop functional and structural alterations in hypertension. However, the mechanisms of this remodeling are not fully understood.We hypothesized that altered gene expression is associated with the development of ...
Arribas, Silvia M. +9 more
core +14 more sources
Withdrawn: MiR‐132‐3p promotes neuroinflammation and dopaminergic neurodegeneration by suppressing glutaredoxin expression [PDF]
Journal of Neurochemistry, 2021 This study aimed to investigate the effect of miR-132-3p/GLRX on neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease (PD). In clinical experiments, the levels of miR-132-3p and glutaredoxin (GLRX) in the midbrain tissuesfrom 5 patients with PD were analyzed by qRT-PCR and Western blotting.
openaire +2 more sources
Molecular Carcinogenesis, 2023 AbstractEpidemiological evidence supports that consumption of high‐temperature food and beverages is an important risk factor for esophageal squamous cell carcinoma (ESCC); however, the underlying mechanism still remains unclear. Here, we established a series of animal models and found that drinking 65°C water can promote esophageal tumor progression ...
Jing Wang +16 more
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Aberrant expression of microRNA-132-3p and microRNA-146a-5p in Parkinson’s disease patients
Open Life Sciences, 2020 Parkinson’s disease (PD) is an age-related neurodegenerative disorder which is assessed based on the motor symptoms. A number of microRNAs (miRNAs) are dysregulated and involved in the pathogenesis or development of PD.
Shu Yu, Qian Jinjun, Wang Chunyan
doaj +1 more source
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate muscle atrophy via the miR-132-3p/FoxO3 axis. [PDF]
J Orthop TranslatMuscle atrophy or sarcopenia is the loss of muscle mass and strength and leads to an increased risk of disability and death including osteoporotic fractures. Currently, there are no available clinical biologic agents for the treatment of sarcopenia. Since exosomes have become increasingly attractive as a novel therapeutic approach due to their ability ...
Ma H +8 more
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