Results 71 to 80 of about 54,811 (219)

Decreased exosome-delivered miR-486-5p is responsible for the peritoneal metastasis of gastric cancer cells by promoting EMT progress

World Journal of Surgical Oncology, 2021
Background The present study aims to investigate the preliminary mechanism underlying the peritoneal metastasis of gastric cancer cells. Methods Exosomes from GC9811 cells (Con-Exo) and from GC9811-P cells (PM-Exo) were extracted by ultracentrifugation ...
Xian-Ming Lin, Zhi-Jiang Wang, Yu-Xiao Lin, Hao Chen   +3 more
doaj   +1 more source

Endogenous reference RNAs for microRNA quantitation in formalin-fixed, paraffin-embedded lymph node tissue [PDF]

, 2018
Lymph node metastasis is one of the most important factors for tumor dissemination. Quantifying microRNA (miRNA) expression using real-time PCR in formalin-fixed, paraffin-embedded (FFPE) lymph node can provide valuable information regarding the ...
Cho-Isoda Yukiko, Hori Mitsuo, Iijima Tatsuo, Inada Katsushige, Ishiguro Shingo, Kojima Hiroshi, Oki Akinori, Okoshi Yasushi, Saito Hitoaki, Shimazui Toru, Suzuki Hisashi, Tamaki Yoshio, 大越 靖, 小島 寛, 島居 徹, 沖 明典, 玉木 義雄, 鈴木 久史   +17 more
core   +2 more sources

Candidate alzheimer’s disease biomarker mir-483-5p lowers tau phosphorylation by direct erk1/2 repression [PDF]

, 2021
MicroRNAs have been demonstrated as key regulators of gene expression in the etiology of a range of diseases including Alzheimer’s disease (AD). Recently, we identified miR-483-5p as the most upregulated miRNA amongst a panel of miRNAs in blood plasma ...
Fesiuk, A, Laskowska-Kaszub, K, Logarinho, E, Nagaraj, S, Vaz, S, Want, A, Wojda, U   +6 more
core   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Differential effects on the miRNome of the treatment of human airway epithelial Calu-3 cells with peptide-nucleic acids (PNAs) targeting microRNAs miR-101-3p and miR-145-5p: Next generation sequencing datasets

Data in Brief, 2021
Since the demonstration that microRNAs are deeply involved in the regulation of Cystic Fibrosis (CF) Transmembrane Conductance Regulator (CFTR) gene, a great attention has been dedicated to possible alteration of the CFTR gene expression by targeting ...
Jessica Gasparello, Enrica Fabbri, Roberto Gambari, Alessia Finotti   +3 more
doaj   +1 more source

miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells [PDF]

, 2017
Tip110 expression regulates hematopoiesis, but the regulatory mechanisms during hematopoiesis are not fully understood. There are a number of putative microRNA (miRNA) binding sites identified within the Tip110 3' untranslated region (3'UTR).
Broxmeyer, Hal E., He, Johnny J., Huang, Xinxin, Liu, Ying, Timani, Khalid A.   +4 more
core   +3 more sources

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Rapid regulation of microRNA following induction of long-term potentiation in vivo.

Frontiers in Molecular Neuroscience, 2014
Coordinated regulation of gene expression is essential for consolidation of the memory mechanism, long-term potentiation (LTP). Triggering LTP by N-methyl-D-aspartate receptor (NMDAR) activation rapidly activates constitutive and inducible transcription ...
Greig eJoilin, Greig eJoilin, Diane eGuévremont, Diane eGuévremont, Brigid eRyan, Brigid eRyan, Charles eClaudianos, Alexandre Santos Cristino, Wickliffe Carson Abraham, Wickliffe Carson Abraham, Joanna Margaret Williams, Joanna Margaret Williams   +11 more
doaj   +1 more source

MicroRNAs regulating macrophages infected with Leishmania L. (V.) Braziliensis isolated from different clinical forms of American tegumentary leishmaniasis

Frontiers in Immunology, 2023
BackgroundLeishmaniasis is an infectious disease caused by protozoa of the genus Leishmania. There are still no vaccines, and therapeutic options are limited, indicating the constant need to understand the fine mechanisms of its pathophysiology.
Tainã Lago, Tainã Lago, Tainã Lago, Lilian Medina, Lilian Medina, Jamile Lago, Jamile Lago, Jamile Lago, Nadja Santana, Nadja Santana, Thiago Cardoso, Thiago Cardoso, Alan Rocha, Thyago Leal-Calvo, Edgar M. Carvalho, Edgar M. Carvalho, Edgar M. Carvalho, Edgar M. Carvalho, Léa Cristina Castellucci, Léa Cristina Castellucci, Léa Cristina Castellucci   +20 more
doaj   +1 more source

Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells [PDF]

, 2016
Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs).
Braakman, E. (Eric), Chiba, H. (Hideki), Cornelissen, J.J. (Jan), Dudakovic, A. (Amel), Eerden, B.C.J. (Bram) van der, Leeuwen, J.P.T.M. (Hans) van, Morhayim, J. (Jess), Peppel, J. (Jeroen) van de, Raaijmakers, M.H.G.P. (Marc), Rombouts, E.W.J.C. (Elwin W. J. C.), Ter Borg, M.N.D. (Mariëtte N. D.), Wijnen, A.J. (André) van   +11 more
core   +1 more source