Results 171 to 180 of about 6,191 (242)

Bypassing the brain barriers: upregulation of serum miR-495 and miR-543-3p reflects thyroid-mediated developmental neurotoxicity in the rat. [PDF]

Toxicol Sci
O'Shaughnessy KL, Sasser AL, Bell KS, Riutta C, Ford JL, Grindstaff RD, Gilbert ME.   +6 more
europepmc   +1 more source

Correction: Down-regulation of miR-543 expression increases the sensitivity of colorectal cancer cells to 5-Fluorouracil through the PTEN/PI3K/AKT pathway. [PDF]

Biosci Rep, 2022
europepmc   +1 more source

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

Environmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings   +15 more
wiley   +1 more source

Stigma, attitude, and knowledge of epilepsy in Italy: A survey on 1159 subjects

Epilepsia Open, EarlyView.
Abstract Objective Stigma remains a major determinant of impaired quality of life (QoL) in people with epilepsy (PwE). We aimed to investigate perceptions of epilepsy‐related stigma in the Italian general population, assess knowledge of epilepsy and seizure first aid, and identify factors associated with stigmatizing attitudes.
Marina Romozzi, Federico Tosto, Raffaele Turano, Lapo Sbrenna, Davide Chiffi, Flavia Bianchi, Vincenzo Trigila, Catello Vollono, Giovanni Assenza, Mario Tombini, Paolo Calabresi, Sonia Di Tella, Luigi Francesco Iannone   +12 more
wiley   +1 more source

Age‐Related Trends in Eating‐Pathology Symptoms Among Sexual Minority Adults

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To examine how eating‐disorder symptoms vary by chronological age and sexual orientation in sexual minority adults. Method Cross‐sectional data came from 2062 cisgender sexual minority participants (925 gay men, 573 lesbian women, 116 bi+ men, 448 bi+ women; age = 47.8 years, range = 18–96).
Jason M. Nagata, Christopher D. Otmar, Char Potes, Ken Murakami, Jason M. Lavender, Emilio J. Compte, Tiffany A. Brown, Kelsie T. Forbush, Annesa Flentje, Micah E. Lubensky, Juno Obedin‐Maliver, Mitchell R. Lunn   +11 more
wiley   +1 more source

Surface Charge‐Determined Protein Coronas of Nanoparticles Control Endothelial Cells Uptake Under Low Magnitude Shear Stress

Exploration, EarlyView.
To elucidate the mechanisms underlying NPs‐ECs interactions under hemodynamic conditions, our study reveals that low magnitude shear stress (LSS and OSS) enhances the uptake of nNPs by ECs, which exhibit a pronounced tendency to accumulate at atherosclerotic plaque sites in ApoE−/− mice.
Hongping Zhang, Shuang Zhao, Qianting Zhang, Chengchen Deng, Chuanrong Zhao, Xiangxiu Wang, Anna Malashicheva, Yi Wang, Juhui Qiu, Guixue Wang   +9 more
wiley   +1 more source

EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

Exploration, EarlyView.
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similarities with cystic epithelial cells in ADPKD. This study
Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang   +15 more
wiley   +1 more source

Public Perceptions and Engagement for Carbon Capture, Utilization, and Storage: Literature Review With a Case Study of Utah, USA

Greenhouse Gases: Science and Technology, EarlyView.
ABSTRACT Carbon dioxide capture, utilization, and storage (CCUS) is a potential key to mitigating anthropogenic CO2 emissions and associated impacts on global climate change. Successful CCUS deployment hinges on both technological advancements and public support.
Ting Xiao, Erin Middleton, Omar Bakelli, Sophia Cheng, Danyang Zhu, Lei Xu, Brian McPherson   +6 more
wiley   +1 more source

LncRNA PCAT6 Accelerates the Progression and Chemoresistance of Cervical Cancer Through Up-Regulating ZEB1 by Sponging miR-543. [PDF]

Onco Targets Ther, 2020
Ma Z, Gu G, Pan W, Chen X.
europepmc   +1 more source

Spin‐Crossover Modulated Luminescence in Materials and Molecular Complexes

Helvetica Chimica Acta, EarlyView.
The synergistic coupling of spin‐crossover and luminescent properties holds great promise for the development of multifunctional and stimuli‐responsive molecular materials. This contribution provides a comprehensive overview of the field, surveying the possible coupling mechanisms, the various synthetic strategies and their potential applicability, as ...
Charlotte Egger, Claude Piguet
wiley   +1 more source