Results 231 to 240 of about 6,191 (242)

LINC01082 Inhibits Non-Small Cell Lung Cancer by Targeting the miR-543/TNRC6A Axis

Biochemical Genetics, 2023
Non-small cell lung cancer (NSCLC) accounts for over 80% of lung cancer cases and have poor clinical outcomes. Increasing number of lncRNAs are reported to be implicated in the carcinogenesis of NSCLC. Previous lncRNA-seq results showed that LINC01082 was under-expressed in several cancer types. In the current study, we focused on the role of LINC01082
Ran, Yang, Jinli, Han, Song, Zhao
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Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1

Biochemical and Biophysical Research Communications, 2015
Insulin resistance plays an important role in the development of hypertension, which is seriously detrimental to human health. Recently, Sirtuin-1 (SIRT1) has been found to participate in regulation of insulin resistance. Therefore, further studies focused on the SIRT1 regulators might provide a potential approach for combating insulin resistance and ...
Xiaojing, Hu, Liyi, Chi, Wentao, Zhang, Tiao, Bai, Wei, Zhao, Zhanbin, Feng, Hongyan, Tian   +6 more
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CircCCL22 Regulates CDC25A via Sponging miR-543 and Promotes Proliferation and Metastasis in Endometrial Cancer

Molecular Biotechnology, 2023
Endometrial cancer (EC) is the most common gynecological tumor. Circular RNAs are a novel type of non-coding RNA that have important regulatory functions, particularly in the pathogenic progression of cancer. In this study, we investigated the function of circCCL22, and elucidated its molecular mechanism in EC progresssion. The expression of circCCL22,
Sichao Liu, Min Wang, Xianglin Lv, Jing Zhou, Le Gao   +4 more
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MiR‐543 regulates myoblast proliferation and differentiation of C2C12 cells by targeting KLF6

Journal of Cellular Biochemistry, 2020
AbstractMicroRNA‐543 (miR‐543) has been found to play a suppressive role in various human cancers in many studies, whereas the specific functions of miR‐543 in muscle development remain poorly understood. Here, we found that the expression of miR‐543 was high in skeletal muscle and increased during the differentiation of C2C12 cells.
Tingting Kang, Wenkai Xing, Yu Xi, Kun Chen, Mengsi Zhan, Xiaoyin Tang, Yueying Wang, Ruirui Zhang, Minggang Lei   +8 more
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Circ_0026123 promotes cisplatin resistance and progression of ovarian cancer by upregulating RAB1A through sequestering miR-543

Anti-Cancer Drugs, 2022
Background Circular RNAs can act as critical regulators in the tumorigenesis and chemoresistance of ovarian cancer (OC). Herein, this work aimed to probe the function and mechanism of circ_0026123 in the cisplatin (DDP) resistance and progression of OC and its potential value in the clinic ...
Lei, Wei, Weicai, He, Hua, Zhao, Peixi, Zhao   +3 more
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MiR-543 Regulates the Development of Chronic Obstructive Pulmonary Disease by Targeting Interleukin-33

Clinical Laboratory, 2018
This main aim of the study was to evaluate the expression and specific role of miR-543 in the progression of chronic obstructive pulmonary disease (COPD), thereby evaluating their diagnostic ability and treatment in COPD patients.Real time PCR was carried out to explore the level of miR-543 in the plasma and lung tissues of COPD patients and controls ...
Huozhen, He, Haichao, Wang, Fuyang, Pei, Meng, Jiang   +3 more
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Hsa_circ_0092355 Accelerates Papillary Thyroid Cancer Progression by Regulating the miR-543/PDE5A Pathway

Hormone and Metabolic Research
AbstractCircRNAs have been found to participate in the progression of various tumors. In the present study, we aimed to clarify the role of hsa_circ_0092355 in papillary thyroid cancer (PTC) cell development. RT-qPCR was used to determine the expression of hsa_circ_0092355, miR-543, and PDE5A.
Zhijun, Sun, Min, Zhang, Yangmei, Ye, Leilei, Yang   +3 more
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miR-543 promoted the cell proliferation and invasion of nasopharyngeal carcinoma by targeting the JAM-A

Human Cell, 2019
MicroRNAs (miRNAs) are defined as small, non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysfunction of miRNAs was involved in the initiation and progression of nasopharyngeal carcinoma (NPC). Here, we found that miR-543 was markedly overexpressed in NPC tissues and cell lines.
Xue Jiang, Baoqiang Dai, Lichun Feng
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Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer

Cancer Biotherapy and Radiopharmaceuticals, 2020
Background: Long noncoding RNA SNHG10 has been reported to promote the development of liver cancer. While by analyzing The Cancer Genome Atlas (TCGA) dataset we observed the downregulation of SNHG10 in non-small cell lung cancer (NSCLC). This study aimed to investigate the roles of SNHG10 in NSCLC. Materials and Methods: This study included 60 pairs of
Zhe, Zhang, Li, Nong, Meng-Lei, Chen, Xiao-Li, Gu, Wei-Wei, Zhao, Ming-Hui, Liu, Wen-Wu, Cheng   +6 more
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Regulatory Mechanism of miR-543-3p on GLT-1 in a Mouse Model of Parkinson’s Disease

ACS Chemical Neuroscience, 2019
Parkinson's disease (PD) features the degeneration and death of dopamine neurons in the substantia nigra pars compacta and the formation of Lewy bodies that contain α-synuclein. Among the numerous PD etiologies, glutamate excitotoxicity is a research hot spot, and glutamate transporters play key roles in this theory.
Xiaojuan Wu, Xingjun Meng, Feng Tan, Zhigang Jiao, Xiuping Zhang, Huichun Tong, Xiaoliang He, Xiaodong Luo, Pingyi Xu, Shaogang Qu   +9 more
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