Results 41 to 50 of about 32,139,398 (268)

miR-105 and miR-767 do not alter expression of AKT isoforms or PI3K subunits.

, 2022
A549 cells were treated with a negative control miRNA (Control), miR-105 and miR-767 (miR), ZSTK474 alone, or ZSTK474 and miR-105/767 (ZSTK474 + miR). Gene expression was measured by qPCR. Each treatment condition included three replicates.
Guanying Bianca Xu (12700306), Laura Moody (4054255), Yuan-Xiang Pan (9369757), Hong Chen (108084)   +3 more
core   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma

Clinical Epigenetics, 2019
Background Efficient treatments against metastatic melanoma dissemination are still lacking. Here, we report that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevent in vitro 3D invasiveness of metastatic melanoma ...
Cécile Desjobert, Arnaud Carrier, Audrey Delmas, Diego M. Marzese, Antoine Daunay, Florence Busato, Arnaud Pillon, Jörg Tost, Joëlle Riond, Gilles Favre, Chantal Etievant, Paola B. Arimondo   +11 more
doaj   +1 more source

MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1. [PDF]

PLoS ONE, 2012
Activating mutations in the receptor tyrosine kinase FLT3 are one of the most frequent somatic mutations in acute myeloid leukemia (AML). Internal tandem duplications of the juxtamembrane region of FLT3 (FLT3/ITD) constitutively activate survival and ...
Kyu-Tae Kim, Adam P Carroll, Baratali Mashkani, Murray J Cairns, Donald Small, Rodney J Scott   +5 more
doaj   +1 more source

S12D-Pelecanimorphae-Overlap-mir

, 2019
S12D File. Set of Maximally Informative Relations (MIR) inferred for the 2015./2014.Pelecanimorphae alignment, with coverage locally relaxed. Total = 200 MIR.
Shizhuo, Yu, Franz, Nico M., Brown, Joseph W., Ludäscher, Bertram, Nico M. Franz (8027303), Joseph W. Brown (8028728), Yu Shizhuo (6373742), Musher, Lukas J., Lukas J. Musher (6368897), Bertram Ludäscher (479396)   +9 more
core   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Role of miRNAs in Normal and Myasthenia Gravis Thymus

Frontiers in Immunology, 2020
The thymus, a primary lymphoid organ, provides a complex environment essential for the generation of the T-cell repertoire. Thymic alterations occur during life either in the context of thymic involution upon aging or the pathophysiological context of ...
Mélanie A. Cron, Émilie Guillochon, Linda Kusner, Rozen Le Panse   +3 more
doaj   +1 more source

miR449_string_hires_image-5-miR-449-miR-34.png

, 2023
miR449_string_hires_image-5-miR-449-miR-34 ...
Federica Monaco (17674014)
core   +1 more source

The novel microRNAs hsa-miR-nov7 and hsa-miR-nov3 are over-expressed in locally advanced breast cancer [PDF]

, 2020
miRNAs are an important class of small non-coding RNAs, which play a versatile role in gene regulation at the post-transcriptional level. Expression of miRNAs is often deregulated in human cancers.
Poduval, Deepak, Straume, Anne Hege, Zuzana Sichmanova (8720604), Anne Hege Straume (8720607), Sichmanovà, Zuzana, Deepak Poduval, Stian Knappskog, Deepak Poduval (8720601), Per Eystein Lønning (8720610), Zuzana Sichmanova, Anne Hege Straume, Knappskog, Stian, Lønning, Per Eystein, Stian Knappskog (53342), Per Eystein Lønning   +14 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source