Results 161 to 170 of about 287,756 (317)
Identification of differentially expressed miRNAs in early-stage cervical cancer with lymph node metastasis across The Cancer Genome Atlas datasets [PDF]
, 2018 Qian Chen,1 Xiaoyun Zeng,2 Dongping Huang,2 Xiaoqiang Qiu2 1Department of Research, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China; 2Department of Epidemiology, School of Public Health, Guangxi Medical University ...
Chen Q, Huang D, Qiu X, Zeng X
core
Advanced Science, EarlyView.Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen +13 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen +11 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai +11 more
wiley +1 more source
microRNA-19a; miRNA-19b; miRNA-21; miRNA-106b∼25 cluster; miRNA-181a; miRNA-181b [PDF]
Science-Business eXchange, 2008 openaire +1 more source
Biomarkers of Sarcopenia: Current Status and Future Perspectives
AGING MEDICINE, EarlyView.In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo +6 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.MiR‐146a‐5p is downregulated in colorectal polyps, leading to IRAK1 upregulation and NF‐κB activation, which promotes M1 macrophage polarization and inflammation. Overexpression of miR‐146a‐5p suppresses IRAK1/NF‐κB signaling, reduces M1 polarization, and alleviates inflammatory responses.
Peng Song +6 more
wiley +1 more source
Delivery of miRNAs Using Nanoparticles for the Treatment of Osteosarcoma [PDF]
Chengran Wang,1,* Yihong Zhang,1,* Weihui Kong,2 Xin’ao Rong,1 Ziming Zhong,1 Lei Jiang,3 Shuhan Chen,1 Chuang Li,1 Fuqiang Zhang,1 Jinlan Jiang1 1Department of Scientific Research Center, China–Japan Union Hospital of Jilin University, Changchun,
Zhang F +9 more
core +1 more source
Advanced Intelligent Discovery, EarlyView.Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz +2 more
wiley +1 more source
Identification of Upregulating Genes, Transcription Factors, and miRNAs in Vitiligo. In silico Study [PDF]
Ahmed Ibrahim AbdElneam,1,2 Mohammed Saleh Al-Dhubaibi,3 Saleh Salem Bahaj,4 Ghada Farouk Mohammed,5 Lina Mohammed Atef5 1Department of Clinical Biochemistry, Department of Basic Medical Sciences, College of Medicine, Shaqra University, Dawadmi, Saudi ...
Mohammed GF +4 more
core +1 more source